![2-[({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)methyl]isonicotinic acid structure](https://static.chemtradehub.com/structs/473/473924-63-9-973b.webp "2-[({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)methyl]isonicotinic acid structure")
2-[({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)methyl]isonicotinic acid
CAS Number:
473924-63-9
Molecular Formula:
C12H16N2O4
Analytical platforms for activity-based protein profiling – exploiting the versatility of chemistry for functional proteomics
Literature Information
Publication Date
2006-04-25
DOI
10.1039/B600653C
Impact Factor
6.222
Authors
Stephan A. Sieber, Benjamin F. Cravatt
View Original
Abstract
The field of proteomics aims to develop and apply technologies for the characterization of protein function on a global scale. Toward this end, synthetic chemistry has played a major role by providing new reagents to profile segments of the proteome based on activity rather than abundance. Small molecule probes for activity-based protein profiling have been created for more than a dozen enzyme classes and used to discover several enzyme activities elevated in disease states. These innovations have inspired complementary advancements in analytical chemistry, where new platforms have been introduced to augment the information content achievable in chemical proteomics experiments. Here, we will review these analytical platforms and discuss how they have exploited the versatility of chemical probes to gain unprecedented insights into the function of proteins in biological samples of high complexity.
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Source Journal
Chemical Communications
CiteScore:
8.6
Self-citation Rate:
4.7%
Articles per Year:
2458
ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry
Recommended Compounds
2-Methyl-2-propanyl (2R)-2-formyl-1-piperidinecarboxylate
CAS Number:
134526-69-5
Molecular Formula:
C11H19NO3
![4-[(2,4-Dihydroxyphenyl)diazenyl]-5-hydroxy-2,7-naphthalenedisulfonic acid structure](https://static.chemtradehub.com/structs/362/3627-01-8-79ac.webp "4-[(2,4-Dihydroxyphenyl)diazenyl]-5-hydroxy-2,7-naphthalenedisulfonic acid structure")
4-[(2,4-Dihydroxyphenyl)diazenyl]-5-hydroxy-2,7-naphthalenedisulfonic acid
CAS Number:
3627-01-8
Molecular Formula:
C16H12N2O9S2
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