(3R)-3-Pyrrolidinol

Basic Information

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CAS Number

2799-21-5

Molecular Formula

C4H9NO

Molecular Weight

87.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Liquid

Melting Point

15 °C

Boiling Point

215-216 °C

Water Solubility

Soluble in water and methanol.

Refractive Index

n20/D 1.488(lit.)

Specific Rotation

6.5 º (c=3.5% in MeOH)

SMILES

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C1CNCC1O

InChI

InChI=1S/C4H9NO/c6-4-1-2-5-3-4/h4-6H,1-3H2/t4-/m1/s1

InChIKey

JHHZLHWJQPUNKB-SCSAIBSYSA-N

LogP

-0.6594

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

46.8

Safety Information

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GHS Hazard Pictograms

H315

H319

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Sensitiveness

Air Sensitive & Hygroscopic

Synonyms & References

English

2799-21-5
(R)-(+)-3-PYRROLIDINOL
3(R)-hydroxypyrrolidine
3-(R)-hydroxypyrrolidine
Q-102903
(R)-3-hydroxylpyrrolidine
(R)-3-Pyrrolidinol, 98%
3-(R)-pyrrolidinol
CS-M0933
(R)-pyrrolidin-3-ol;(R)-3-HYDROXY-PYRROLIDINE
(R)-pyrrolidine-3-ol
(3R)-3-Pyrrolidinol
STR04247
AC-13108
P1608
3-PYRROLIDINOL, (3R)-
PB17129
3-Hydroxy-(R)-pyrrolidine
EN300-67312
MFCD00145220
R-HP
(R)-HYDROXYPYRROLIDINE
( R )-3-Hydroxypyrrolidine
(3R)pyrrolidin-3-ol
(R)-3-Hydroxypyrrolidine
AKOS005174570
(R)-(+)-3-Hydroxypyrrolidine
(R)-3-Pyrrolidinol
(3R)3-pyrrolidinol
A5359
(R)-3-hydroxypyrrolidin

MDL Number

MFCD00145220

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (3R)-3-Pyrrolidinol (CAS: 2799-21-5)?

(3R)-3-Pyrrolidinol is a colorless liquid with a molecular weight of approximately 101.14 g/mol. It has a pKa of about 10.4. The compound is soluble in water and ethanol. Chemically, it is reactive towards bases and can undergo substitution reactions.

How is (3R)-3-Pyrrolidinol (CAS: 2799-21-5) typically synthesized?

(3R)-3-Pyrrolidinol can be synthesized via the Wittig reaction of 3-bromopyrrolidine with phenyl triphenylphosphonium bromide, yielding a high yield of the desired stereoisomer. Other methods include the reduction of 3-bromopyrrolidone with sodium borohydride.

What industries use (3R)-3-Pyrrolidinol (CAS: 2799-21-5)?

(3R)-3-Pyrrolidinol is used in the pharmaceutical industry as a precursor for drugs and in polymer chemistry for the synthesis of functionalized polymers. It also finds applications in the production of sensors and as a ligand in catalysis.

What precautions should be taken when handling (3R)-3-Pyrrolidinol (CAS: 2799-21-5)?

When handling (3R)-3-Pyrrolidinol, use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store in a cool, dry place away from oxidizing agents. In case of spill, neutralize with an acid and dispose of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.