Fmoc-lys(ME,boc)-OH

Basic Information

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CAS Number

951695-85-5

Molecular Formula

C27H34N2O6

Molecular Weight

482.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

85-87 ºC

Boiling Point

665.36 °C at 760 mmHg

Density

1.200

Flash Point

356.197 °C

SMILES

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CC(C)(C)OC(=O)N(C)CCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C27H34N2O6/c1-27(2,3)35-26(33)29(4)16-10-9-15-23(24(30)31)28-25(32)34-17-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h5-8,11-14,22-23H,9-10,15-17H2,1-4H3,(H,28,32)(H,30,31)/t23-/m0/s1

InChIKey

JHMSFOFHTAYQLS-QHCPKHFHSA-N

LogP

5.015500000000005

Topological Polar Surface Area

105.17000000000002 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

714

Synonyms & References

English

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)(methyl)amino)hexanoic acid
Fmoc-Lys(Boc,Me)-OH
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]hexanoic acid
(S)-2-AMINO-6-(METHYLAMINO)HEXANOIC ACID, N6-BOC, N2-FMOC PROTECTED
Fmoc-L-Lys(Boc,Me)-OH
Fmoc-Lys(Boc)(Me)-OH
Fmoc-Lys-(Me,Boc)-OH
Fmoc-Lys(Me,Boc)-OH
AmbotzFAA1448
Fmoc-Lys(Me)(Boc)-OH
Fmoc-L-Lys(Boc)(Me)-OH
N'-[(1,1-Dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-methyl-L-lysine
Fmoc-Lys (Boc) (Me)-OH
JHMSFOFHT
N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-methyl-L-lysine (ACI)
L
(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]hexanoic acid
Nα-Fmoc-Nε-tert-butyloxycarbonyl-Nε-methyl-L-lysine
DTXSID70657020
951695-85-5
Fmoc-Lys(Me,Boc)-OH, AldrichCPR
DB-030099
AKOS016002232
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-t-butyl-oxycarbonyl-N-epsilon-methyl-L-lysine (Fmoc-L-Lys(Boc,Me)-OH)
HY-66024
FMOC-LYS(ME,BOC)-OH
AC-24661
(2S)-6-[(tert-butoxycarbonyl)(methyl)amino]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid
SCHEMBL12346100
(S)-2-Amino-6-(methylamino)hexanoic acid, N6-BOC, N2-FMOC protected
N~6~-(tert-Butoxycarbonyl)-N~2~-{[(9H-fluoren-9-yl)methoxy]carbonyl}-N~6~-methyl-L-lysine

MDL Number

MFCD01861332

FAQ

What are the physical and chemical properties of Fmoc-lys(ME,boc)-OH (CAS: 951695-85-5)?

Fmoc-lys(ME,boc)-OH (CAS: 951695-85-5) is a solid crystalline compound with a molecular weight of approximately 555.44 g/mol. It is sparingly soluble in water but soluble in common organic solvents like DMF and DMSO. This compound is known for its reactivity in peptide coupling reactions and has a pKa around 8.0. It is stable under normal laboratory conditions but should be stored in a desiccator to prevent moisture absorption.

How is Fmoc-lys(ME,boc)-OH (CAS: 951695-85-5) typically synthesized?

Fmoc-lys(ME,boc)-OH is typically synthesized through a multi-step process involving the protection of the lysine amino group with a Fmoc group and subsequent amidation with a boc-protected side chain. This reaction is catalyzed by coupling agents like DIC/HOBt and typically yields a product with a high degree of purity. The synthesis involves careful temperature control and the use of appropriate solvents to ensure high selectivity and yield.

What industries use Fmoc-lys(ME,boc)-OH (CAS: 951695-85-5)?

Fmoc-lys(ME,boc)-OH (CAS: 951695-85-5) is primarily used in the pharmaceutical and biotechnology industries for the synthesis of custom peptides and proteins. It is also utilized in the polymer industry for the development of functional polymers and in the semiconductor industry for the preparation of organic semiconductor materials. Additionally, this compound is used in the production of sensors and other advanced materials.

What precautions should be taken when handling Fmoc-lys(ME,boc)-OH (CAS: 951695-85-5)?

When handling Fmoc-lys(ME,boc)-OH (CAS: 951695-85-5), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, it is crucial to clean up the area immediately using appropriate absorbent materials and to follow the safety data sheet (SDS) for disposal instructions. Always refer to the SDS for detailed safety information and emergency procedures.