p-Toluenesulfonyl azide

Basic Information

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CAS Number

941-55-9

Molecular Formula

C7H7N3O2S

Molecular Weight

197.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

°Cat760mmHg

Density

~0.90 g/mL at 20 °C

Refractive Index

n20/D 1.502

SMILES

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CC1=CC=C(C=C1)S(=O)(=O)N=[N+]=[N-]

InChI

InChI=1S/C7H7N3O2S/c1-6-2-4-7(5-3-6)13(11,12)10-9-8/h2-5H,1H3

InChIKey

NDLIRBZKZSDGSO-UHFFFAOYSA-N

LogP

2.52756

Complexity

302

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H300 Fatal if swallowed
Acute toxicity, oral

H304 May be fatal if swallowed and enters airways
Aspiration hazard

H315 Causes skin irritation
Skin corrosion/irritation

H336 May cause drowsiness or dizziness
Specific target organ toxicity, single exposure; Narcotic effects

H373 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Synonyms & References

English

p-Toluenesulfonyl azide
4-methyl-benzenesulfonylazid
Benzenesulfonylazide,4-methyl-
P-TOLUENESULFONYL AZIDE OR 4-METHYLBENZENESULFONYL AZIDE
4-Methylbenzenesulfonyl azide
Tosyl azide
4-Methylbenzenesulfonic acid azide
p-Methylbenzenesulfonic acid azide
diazonio-(4-methylphenyl)sulfonylazanide
4-Methylbenzenesulfonyl azide (ACI)
p-Toluenesulfonyl azide (6CI, 7CI, 8CI)
4-Methylphenylsulfonyl azide
4-Toluenesulfonyl azide
Azido-p-toluenesulfonic acid
NSC 138649
p-Methylbenzenesulfonyl azide
p-Methylphenylsulfonyl azide
p-Toluenesulfonazide
p-Toluenesulfonic acid azide
p-Tolylsulfonyl azide
p-Tosyl azide
Tosyl nitride
941-55-9
AKOS009237058
p-Toluenesulfonyl azide (8CI)
4-methylbenzene-1-sulfonyl azide
UNII-97F7BLE97S
NS00040169
Q1445465
4-methylbenzenesulfonyl azide
SCHEMBL137120

MDL Number

MFCD00180767

Customs Code

2929909090

FAQ

What are the physical and chemical properties of p-Toluenesulfonyl azide (CAS: 941-55-9)?

p-Toluenesulfonyl azide (CAS: 941-55-9) is a crystalline white solid with a molecular weight of approximately 213.19 g/mol. It has a melting point of 118-121°C and is soluble in organic solvents like dichloromethane and acetone. Chemically, it is highly reactive due to the presence of a nitroso group, making it useful in various chemical reactions.

How is p-Toluenesulfonyl azide (CAS: 941-55-9) typically synthesized?

p-Toluenesulfonyl azide is typically synthesized by the reaction of toluenesulfonyl chloride with sodium azide in an aqueous medium. The process is carried out under mild conditions and yields a high purity product with good selectivity and yield. The reaction is catalyzed by a base, such as sodium carbonate, and is followed by purification using recrystallization.

What industries use p-Toluenesulfonyl azide (CAS: 941-55-9)?

p-Toluenesulfonyl azide (CAS: 941-55-9) is primarily used in the pharmaceutical industry for the synthesis of various biologically active compounds. It is also utilized in the polymer industry for the modification of polymers and in the development of sensors and semiconductors due to its reactivity and functional groups.

What precautions should be taken when handling p-Toluenesulfonyl azide (CAS: 941-55-9)?

When handling p-Toluenesulfonyl azide (CAS: 941-55-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult a Safety Data Sheet (SDS) for detailed safety instructions and emergency procedures.