Amikacin EP Impurity B

Basic Information

View in Editor

CAS Number

927821-99-6

Molecular Formula

C26H50N6O15

Molecular Weight

686.71 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

View in Editor

C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)NC(=O)C(CCN)O

InChI

InChI=1S/C26H50N6O15/c27-3-1-10(34)23(42)31-8-5-9(32-24(43)11(35)2-4-28)22(47-26-19(40)18(39)16(37)12(6-29)44-26)20(41)21(8)46-25-17(38)14(30)15(36)13(7-33)45-25/h8-22,25-26,33-41H,1-7,27-30H2,(H,31,42)(H,32,43)

InChIKey

HVNATBKIPCIZAA-UHFFFAOYSA-N

LogP

-9.557000000000018

Topological Polar Surface Area

381.2699999999999 Å²

Hydrogen Bond Donor/Acceptor

19 / 21

Synonyms & References

English

1,3-Di-HABA Kanamycin A
O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1,N3-bis[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine (ACI)
D
(2S,2'S)-N,N'-((1S,3R,4S,5R,6R)-4-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-5-hydroxycyclohexane-1,3-diyl)bis(4-amino-2-hydroxybutanamide)

FAQ

What are the physical and chemical properties of Amikacin EP Impurity B (CAS: 927821-99-6)?

Amikacin EP Impurity B is a white or off-white crystalline powder. Its molecular weight is approximately 705.89 g/mol. This impurity has a low solubility in water but is soluble in dilute acid solutions. Chemically, it is less reactive compared to the parent compound, amikacin. It does not readily react with common reagents such as acids and bases under standard laboratory conditions.

How is Amikacin EP Impurity B (CAS: 927821-99-6) typically synthesized?

Amikacin EP Impurity B is synthesized through a series of chemical reactions starting from amikacin or its precursors. The process involves acetylation, amidation, and reduction steps. Commonly, acetic anhydride is used as an acetylating agent, and sodium borohydride serves as the reducing agent. The synthesis yields approximately 70-80% purity of the impurity, with high selectivity towards the desired product.

What industries use Amikacin EP Impurity B (CAS: 927821-99-6)?

Amikacin EP Impurity B, though not a pure compound itself, is often used in the pharmaceutical industry as a reference material for quality control and impurity profiling. It is also relevant in academic research for studying the properties and behavior of amikacin and its derivatives. In the pharmaceutical sector, it aids in the development and assessment of amikacin-based drugs.

What precautions should be taken when handling Amikacin EP Impurity B (CAS: 927821-99-6)?

When handling Amikacin EP Impurity B, it is crucial to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.