5-Bromo-8-chloro-1,7-naphthyridine

Basic Information

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CAS Number

909649-06-5

Molecular Formula

C8H4BrClN2

Molecular Weight

243.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

343.5℃/760mmHg

SMILES

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C1=CC2=C(C(=NC=C2Br)Cl)N=C1

InChI

InChI=1S/C8H4BrClN2/c9-6-4-12-8(10)7-5(6)2-1-3-11-7/h1-4H

InChIKey

GEVCHQPTJOFDSA-UHFFFAOYSA-N

LogP

3.045700000000001

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

167

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

5-Bromo-8-chloro-1,7-naphthyridine
5-Bromo-8-chloro-1,7-naphthyridine (ACI)
5-Bromo-8-chloro-[1,7]naphthyridine
5-bromo-8-chloro-1,7-naphthyridine
5-bromo-8-chloro-[1,7]naphthyridine
DB-078846
8-Chloro-5-bromo-1,7-naphthyridine
5-BROMO-8-CHLORO-1,7-NAPHTHYRIDINE(MINIMUM
SY058989
5-BROMO-8-CHLORO-1,7-NAPHTHYRIDINE
GEVCHQPTJOFDSA-UHFFFAOYSA-N
PB20279
J-517145
F1957-0056
P10608
MFCD08567946
SCHEMBL3381245
EN300-238210
AS-50574
CS-0050565
909649-06-5
DTXSID00654683
AKOS002681182

MDL Number

MFCD08567946

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5)?

5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5) is a solid compound with a crystalline form. Its molecular weight is approximately 266.03 g/mol. It has low solubility in water but is more soluble in organic solvents like ethanol and acetonitrile. This compound is known for its moderate reactivity, particularly towards nucleophiles and electrophiles, and it can undergo substitution reactions under various conditions.

How is 5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5) typically synthesized?

5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5) can be synthesized by a multistep process involving bromination and chlorination of naphthyridine. Commonly, the synthesis begins with naphthyridine, which is brominated using bromine in the presence of a Lewis acid like aluminum trichloride. The resulting brominated compound is then treated with phosphorus pentachloride to introduce the chlorine atom. This process requires careful control of reaction conditions to ensure high yield and selectivity.

What industries use 5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5)?

5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5) is primarily used in the pharmaceutical industry for the development of novel drugs. It also finds applications in the synthesis of chromophores for sensors and in the production of certain organic semiconductors. Additionally, it can be used in polymer chemistry for the modification of polymer properties.

What precautions should be taken when handling 5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5)?

When handling 5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be stored in a tightly sealed container in a cool, well-ventilated area away from direct sunlight and heat sources. In case of a spill, it should be handled in a fume hood, and the Material Safety Data Sheet (MSDS) should be consulted for detailed spill procedures. Exposure to this compound should be minimized to avoid potential health risks.