5-Bromo-8-chloro-1,7-naphthyridine(CAS: 909649-06-5)

5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5) is a solid compound with a crystalline form. Its molecular weight is approximately 266.03 g/mol. It has low solubility in water but is more soluble in organic solvents like ethanol and acetonitrile. This compound is known for its moderate reactivity, particularly towards nucleophiles and electrophiles, and it can undergo substitution reactions under various conditions.

5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5) can be synthesized by a multistep process involving bromination and chlorination of naphthyridine. Commonly, the synthesis begins with naphthyridine, which is brominated using bromine in the presence of a Lewis acid like aluminum trichloride. The resulting brominated compound is then treated with phosphorus pentachloride to introduce the chlorine atom. This process requires careful control of reaction conditions to ensure high yield and selectivity.

5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5) is primarily used in the pharmaceutical industry for the development of novel drugs. It also finds applications in the synthesis of chromophores for sensors and in the production of certain organic semiconductors. Additionally, it can be used in polymer chemistry for the modification of polymer properties.

When handling 5-Bromo-8-chloro-1,7-naphthyridine (CAS: 909649-06-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be stored in a tightly sealed container in a cool, well-ventilated area away from direct sunlight and heat sources. In case of a spill, it should be handled in a fume hood, and the Material Safety Data Sheet (MSDS) should be consulted for detailed spill procedures. Exposure to this compound should be minimized to avoid potential health risks.