Akt1 and Akt2-IN-1

Basic Information

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CAS Number

893422-47-4

Molecular Formula

C33H29N7O

Molecular Weight

539.64 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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C1CN(CCC1C2=NC(=NN2)C3=CC=CC=N3)CC4=CC=C(C=C4)C5=C(C=C6C(=N5)C=CNC6=O)C7=CC=CC=C7

InChI

InChI=1S/C33H29N7O/c41-33-27-20-26(23-6-2-1-3-7-23)30(36-28(27)13-17-35-33)24-11-9-22(10-12-24)21-40-18-14-25(15-19-40)31-37-32(39-38-31)29-8-4-5-16-34-29/h1-13,16-17,20,25H,14-15,18-19,21H2,(H,35,41)(H,37,38,39)

InChIKey

BTUWHHFNOHVCMQ-UHFFFAOYSA-N

LogP

5.816800000000005

Topological Polar Surface Area

103.45 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

892

Synonyms & References

English

Akti_2008
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-naphthyridin-5(6H)-one
Akt1 and Akt2-IN-1
Akt1/Akt2-IN-1
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-naphthyridin-5(6H)-one (ACI)
3-Phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one
NSC-789224
DB-010910
3-phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one
Akt Inhibitor 17
893422-47-4
MS-29949
SB19240
AKOS030260386
3-phenyl-2-[4-({4-[5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl]-6H-1,6-naphthyridin-5-one
3-phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one
NSC789224
F85311
3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-1,6-naphthyridin-5(6H)-one
NCGC00485474-01
BTUWHHFNOHVCMQ-UHFFFAOYSA-N
AKOS040741060
CS-5181
BDBM50256713
3-phenyl-2-[4-({4-[3-(pyridin-2-yl)-1H-1,2,4-triazol-5-yl]piperidin-1-yl}methyl)phenyl]-5,6-dihydro-1,6-naphthyridin-5-one
3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one
HY-50862
SCHEMBL1059047
CHEMBL507130

MDL Number

MFCD13184803

FAQ

What are the physical and chemical properties of Akt1 and Akt2-IN-1 (CAS: 893422-47-4)?

Akt1 and Akt2-IN-1 (CAS: 893422-47-4) is a crystalline compound with a molecular weight of approximately 445.5 g/mol. It has a high solubility in DMSO (dimethyl sulfoxide) and moderate solubility in water. The compound is relatively stable under normal conditions but can react with reducing agents. It is commonly used in pharmaceutical research for its selective inhibition of Akt1 and Akt2 kinases.

How is Akt1 and Akt2-IN-1 (CAS: 893422-47-4) typically synthesized?

Akt1 and Akt2-IN-1 (CAS: 893422-47-4) is typically synthesized through a multi-step process involving the condensation of a protected amino acid with a phosphonate ester. The process requires the use of specific catalysts such as HOBt (1-hydroxybenzotriazole) and DCC (dicyclohexylcarbodiimide). The synthetic route is designed to achieve high selectivity and yield, with purification steps including column chromatography and recrystallization.

What industries use Akt1 and Akt2-IN-1 (CAS: 893422-47-4)?

Akt1 and Akt2-IN-1 (CAS: 893422-47-4) is primarily used in the pharmaceutical industry for research on Akt1 and Akt2 kinases. It is also of interest in the development of potential therapeutic agents for diseases such as cancer and diabetes. The compound has applications in research related to signal transduction pathways and cellular responses.

What precautions should be taken when handling Akt1 and Akt2-IN-1 (CAS: 893422-47-4)?

When handling Akt1 and Akt2-IN-1 (CAS: 893422-47-4), it is important to follow standard laboratory safety protocols. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from direct sunlight. In the event of a spill, neutralize the compound with an appropriate reagent and clean the area thoroughly. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.