Akt1 and Akt2-IN-1(CAS: 893422-47-4)

Akt1 and Akt2-IN-1 (CAS: 893422-47-4) is a crystalline compound with a molecular weight of approximately 445.5 g/mol. It has a high solubility in DMSO (dimethyl sulfoxide) and moderate solubility in water. The compound is relatively stable under normal conditions but can react with reducing agents. It is commonly used in pharmaceutical research for its selective inhibition of Akt1 and Akt2 kinases.

Akt1 and Akt2-IN-1 (CAS: 893422-47-4) is typically synthesized through a multi-step process involving the condensation of a protected amino acid with a phosphonate ester. The process requires the use of specific catalysts such as HOBt (1-hydroxybenzotriazole) and DCC (dicyclohexylcarbodiimide). The synthetic route is designed to achieve high selectivity and yield, with purification steps including column chromatography and recrystallization.

Akt1 and Akt2-IN-1 (CAS: 893422-47-4) is primarily used in the pharmaceutical industry for research on Akt1 and Akt2 kinases. It is also of interest in the development of potential therapeutic agents for diseases such as cancer and diabetes. The compound has applications in research related to signal transduction pathways and cellular responses.

When handling Akt1 and Akt2-IN-1 (CAS: 893422-47-4), it is important to follow standard laboratory safety protocols. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from direct sunlight. In the event of a spill, neutralize the compound with an appropriate reagent and clean the area thoroughly. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.