7-Chloroquinoline-3-carboxylic acid

Basic Information

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CAS Number

892874-49-6

Molecular Formula

C10H6ClNO2

Molecular Weight

207.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

382.122 ℃ at 760 mmHg

SMILES

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C1=CC(=CC2=NC=C(C=C21)C(=O)O)Cl

InChI

InChI=1S/C10H6ClNO2/c11-8-2-1-6-3-7(10(13)14)5-12-9(6)4-8/h1-5H,(H,13,14)

InChIKey

UFGQWTWQNIGAEB-UHFFFAOYSA-N

LogP

2.5864000000000003

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

234

Synonyms & References

English

7-Chloroquinoline-3-carboxylic acid
3-Quinolinecarboxylicacid, 7-chloro-
7-Chloro-3-quinolinecarboxylic acid (ACI)
7-chloroquinoline-3-carboxylic acid
SCHEMBL7955678
7-chloro-3-quinolinecarboxylic acid
AS-39067
DTXSID60588874
AB45107
MFCD08437567
7-Chloroquinoline-3-carboxylic acid, AldrichCPR
AKOS015851323
J-519226
SY128742
892874-49-6
7-Chloroquinoline-3-carboxylicacid
7-Chloro-quinoline-3-carboxylic acid
DB-078368

MDL Number

MFCD08437567

FAQ

What are the physical and chemical properties of 7-Chloroquinoline-3-carboxylic acid (CAS: 892874-49-6)?

7-Chloroquinoline-3-carboxylic acid is a white crystalline solid with a molecular weight of approximately 213.01 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, showing basic properties due to the presence of the carboxylic acid group. It can react with bases to form salts and with certain reagents to undergo substitution reactions.

How is 7-Chloroquinoline-3-carboxylic acid (CAS: 892874-49-6) typically synthesized?

7-Chloroquinoline-3-carboxylic acid is typically synthesized by the condensation of 7-chloroquinoline with acetic anhydride in the presence of a catalyst such as sulfuric acid. The reaction is carried out under mild conditions, and the yield is usually around 70-80%. The product is purified by recrystallization from an appropriate solvent.

What industries use 7-Chloroquinoline-3-carboxylic acid (CAS: 892874-49-6)?

7-Chloroquinoline-3-carboxylic acid is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly for the development of antimalarial drugs. Additionally, it is used in the production of dyes, pigments, and other organic compounds. Due to its chemical reactivity, it also finds applications in sensor technologies and as a precursor in semiconductor manufacturing.

What precautions should be taken when handling 7-Chloroquinoline-3-carboxylic acid (CAS: 892874-49-6)?

When handling 7-Chloroquinoline-3-carboxylic acid, appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled carefully, and the area should be ventilated until the spill is cleaned up. It is recommended to follow the safety data sheet (SDS) for detailed handling instructions and emergency procedures.