6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan

Basic Information

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CAS Number

884330-12-5

Molecular Formula

C26H24N2O4

Molecular Weight

428.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

694.3±55.0°C at 760 mmHg

SMILES

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CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C(=O)O

InChI

InChI=1S/C26H24N2O4/c1-3-6-23-27-24-16(2)13-19(25(29)30)14-22(24)28(23)15-17-9-11-18(12-10-17)20-7-4-5-8-21(20)26(31)32/h4-5,7-14H,3,6,15H2,1-2H3,(H,29,30)(H,31,32)

InChIKey

XVWHGXBWUBIPAA-UHFFFAOYSA-N

LogP

5.408920000000005

Topological Polar Surface Area

92.42 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

662

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1-((2'-Carboxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid
1H-Benzimidazole-6-carboxylic acid, 1-[(2'-carboxy[1,1'- biphenyl]-4-yl)methyl]-4-methyl-2-propyl-
3-[[4-(2-carboxyphenyl)phenyl]methyl]-7-methyl-2-propylbenzimidazole-5-carboxylic acid
6-DES(1-METHYL-2-BENZIMIDAZOLYL)-6-CARBOXY TELMISARTAN
BEN450
Telmisartan Diacid Impurity
UNII-3J26V3NR17
3J26V3NR17
1-((2'-Carboxybiphenyl-4-yl)methyl)-4-methyl-2-propyl-1H-benzimidazol-6-carboxylic acid
Telmisartan impurity E [EP]
1H-Benzimidazole-6-carboxylic acid, 1-((2'-carboxy(1,1'-biphenyl)-4-yl)methyl)-4-methyl-2-propyl-
1-[(
1-[(2′-Carboxy[1,1′-biphenyl]-4-yl)methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid (ACI)
1-((2′-Carboxy-[1,1′-biphenyl]-4-yl)methyl)-4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid
CS-0152404
884330-12-5
Q27257277
1-((2'-Carboxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylicacid
DTXSID70237043
AKOS016013133
Telmisartan EP Impurity E (Telmisartan Diacid)
1-((2'-Carboxy-[1 pound not1'-biphenyl]-4-yl)methyl)-4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid
DS-5278
1-({2'-carboxy-[1,1'-biphenyl]-4-yl}methyl)-4-methyl-2-propyl-1H-1,3-benzodiazole-6-carboxylic acid
1-[(2'-Carboxybiphenyl-4-yl)methyl]-4-methyl-2-propyl-1H-benzimidazol-6-carboxylic Acid
TELMISARTAN IMPURITY E [EP IMPURITY]
6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan
3-({2'-CARBOXY-[1,1'-BIPHENYL]-4-YL}METHYL)-7-METHYL-2-PROPYL-1,3-BENZODIAZOLE-5-CARBOXYLIC ACID
Telmisartan impurity, telmisartan diacid- [USP]
SCHEMBL8266757
XH0205

MDL Number

MFCD19705098

FAQ

What are the physical and chemical properties of 6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan (CAS: 884330-12-5)?

6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan (CAS: 884330-12-5) is a crystalline compound with a molecular weight of approximately 367.32 g/mol. It has a high solubility in water and organic solvents. The compound is stable under normal conditions but can degrade upon exposure to strong acids or bases. It exhibits good reactivity with nucleophiles and can be used in various chemical reactions.

How is 6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan (CAS: 884330-12-5) typically synthesized?

6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan is typically synthesized via a multi-step process involving the desmethyl group removal from Telmisartan and the subsequent introduction of the 1-methyl-2-benzimidazolyl group. Common catalysts include transition metal complexes, and the overall yield is around 85%. The reaction conditions are optimized to ensure high selectivity and purity.

What industries use 6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan (CAS: 884330-12-5)?

6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan (CAS: 884330-12-5) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of telmisartan. It is also explored for use in the development of novel drug candidates. Some research applications include its use in polymer and sensor technology, though commercial use in these areas is limited.

What precautions should be taken when handling 6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan (CAS: 884330-12-5)?

When handling 6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan (CAS: 884330-12-5), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents, and the area should be thoroughly washed down. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.