2-Fluoro-6-nitro-N-phenylbenzamide

Basic Information

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CAS Number

870281-83-7

Molecular Formula

C13H9FN2O3

Molecular Weight

260.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

163-165℃

Density

1.411±0.06 g/cm3 (20℃ 760 Torr)

SMILES

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O=C(c1c(F)cccc1[N+](=O)[O-])Nc1ccccc1

InChI

InChI=1S/C13H9FN2O3/c14-10-7-4-8-11(16(18)19)12(10)13(17)15-9-5-2-1-3-6-9/h1-8H,(H,15,17)

InChIKey

GQVRPSFDUVNMDA-UHFFFAOYSA-N

Complexity

339

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-fluoro-6-nitro-N-phenylbenzamide
Benzamide, 2-fluoro-6-nitro-N-phenyl-
GQVRPSFDUVNMDA-UHFFFAOYSA-N
BBL101363
STL555159
AK470814
2-Fluoro-6-nitro-N-phenylbenzamide, AldrichCPR

MDL Number

MFCD16875530

FAQ

What are the physical and chemical properties of 2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7)?

2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7) is a crystalline solid with a molecular weight of approximately 290.13 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. The compound is moderately reactive, particularly with reducing agents, and exhibits weak acidic behavior due to the nitro group. It is stable under normal conditions but should be stored in a dry, cool place to prevent hydrolysis.

How is 2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7) typically synthesized?

2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7) can be synthesized via a multi-step process, starting with the nitration of 2-fluorobenzamide. The nitro group is introduced using a mixture of fuming nitric acid and sulfuric acid. Subsequently, the phenyl substituent is introduced via coupling with phenyl isocyanate in the presence of a base like triethylamine. The reaction is typically carried out in an organic solvent such as dichloromethane, with yields ranging from 60-80%.

What industries use 2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7)?

2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a precursor for the production of functional polymers, and in sensor technology for developing sensors that can detect specific chemical compounds. Additionally, it is used in some semiconductor applications due to its electronic properties.

What precautions should be taken when handling 2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7)?

When handling 2-Fluoro-6-nitro-N-phenylbenzamide (CAS: 870281-83-7), it is crucial to follow standard safety protocols. It should be stored in a cool, dry place, away from sources of heat and light. Gloves and safety goggles should be worn at all times. The compound should be handled in a well-ventilated fume hood to minimize exposure to fumes. In case of a spill, the area should be flushed with water, and the material should be collected and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.