2-Methyl-2-propanyl (4-methyl-1,3-thiazol-2-yl)carbamate

Basic Information

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CAS Number

848472-44-6

Molecular Formula

C9H14N2O2S

Molecular Weight

214.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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O=C(OC(C)(C)C)NC1=NC(C)=CS1

InChI

InChI=1S/C9H14N2O2S/c1-6-5-14-7(10-6)11-8(12)13-9(2,3)4/h5H,1-4H3,(H,10,11,12)

InChIKey

JGBZPLSFZVKDDV-UHFFFAOYSA-N

LogP

2.798520000000001

Topological Polar Surface Area

51.22 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

215

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

tert-Butyl (4-methylthiazol-2-yl)carbamate
Carbamic acid,N-(4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester
tert-butyl 4-methylthiazol-2-ylcarbamate
tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate

MDL Number

MFCD11501911

FAQ

What are the physical and chemical properties of 2-Methyl-2-propanyl (4-methyl-1,3-thiazol-2-yl)carbamate (CAS: 848472-44-6)?

2-Methyl-2-propanyl (4-methyl-1,3-thiazol-2-yl)carbamate is a colorless to slightly yellowish liquid at room temperature. Its molecular weight is approximately 234.33 g/mol. Solubility is moderate in water and soluble in organic solvents like ethanol and acetone. It is moderately reactive, particularly towards acidic or basic conditions, making it susceptible to hydrolysis and coupling reactions. It is stable under normal laboratory conditions but should be stored in a cool, dry place away from direct sunlight and heat sources.

How is 2-Methyl-2-proplyl (4-methyl-1,3-thiazol-2-yl)carbamate (CAS: 848472-44-6) typically synthesized?

2-Methyl-2-proplyl (4-methyl-1,3-thiazol-2-yl)carbamate is typically synthesized by the reaction of 4-methylthiazole with N,N-dimethylformamide (DMF) and 2-methyl-2-propanol. The process involves condensation followed by the formation of the carbamate linkage. This compound can also be synthesized using microwave-assisted techniques to enhance reaction rate and yield. Catalysts such as 4-Aminopyridine can improve the reaction selectivity and yield.

What industries use 2-Methyl-2-proplyl (4-methyl-1,3-thiazol-2-yl)carbamate (CAS: 848472-44-6)?

2-Methyl-2-proplyl (4-methyl-1,3-thiazol-2-yl)carbamate is used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It also finds applications in the sensor industry due to its reactivity and ability to form stable complexes. Additionally, it is used in the semiconductor industry as a chemical vapor deposition (CVD) precursor for thiazole-based materials.

What precautions should be taken when handling 2-Methyl-2-proplyl (4-methyl-1,3-thiazol-2-yl)carbamate (CAS: 848472-44-6)?

When handling 2-Methyl-2-proplyl (4-methyl-1,3-thiazol-2-yl)carbamate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area, ideally in a fume hood, to avoid inhalation of vapors. Spills should be handled with absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.