2-Chloro-3-hydroxy-4-quinolinecarboxylic acid

Basic Information

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CAS Number

847547-91-5

Molecular Formula

C10H6ClNO3

Molecular Weight

223.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

377.6°C at 760 mmHg

Density

1.6

Flash Point

182.1°C

Refractive Index

1.732

SMILES

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c1ccc2c(c1)c(c(c(n2)Cl)O)C(=O)O

InChI

InChI=1S/C10H6ClNO3/c11-9-8(13)7(10(14)15)5-3-1-2-4-6(5)12-9/h1-4,13H,(H,14,15)

InChIKey

RPGQCGYSROBDNQ-UHFFFAOYSA-N

LogP

2.2920000000000003

Topological Polar Surface Area

70.42 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Synonyms & References

English

2-Chloro-3-hydroxyquinoline-4-carboxylic acid
2-CHLORO-3-HYDROXY-4-QUINOLINECARBOXYLIC ACID
4-Quinolinecarboxylic acid, 2-chloro-3-hydroxy-
4-Quinolinecarboxylicacid,2-chloro-3-hydroxy-(9CI)
2-chloro-3-hydroxyquinoline-4-carboxylic acid

MDL Number

MFCD11706991

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 2-Chloro-3-hydroxy-4-quinolinecarboxylic acid (CAS: 847547-91-5)?

2-Chloro-3-hydroxy-4-quinolinecarboxylic acid is a crystalline solid with a molecular weight of approximately 237.6 g/mol. It is slightly soluble in water and ethanol. The compound is known for its stability under normal conditions but can react with strong bases to form the corresponding salts. It has a pKa of about 5.5, indicating it is a weak acid.

How is 2-Chloro-3-hydroxy-4-quinolinecarboxylic acid (CAS: 847547-91-5) typically synthesized?

2-Chloro-3-hydroxy-4-quinolinecarboxylic acid is typically synthesized through the chlorination of a hydroxyquinoline derivative followed by carboxylation. Commonly used reagents include phosphorous pentachloride for chlorination and chloroacetic anhydride for carboxylation. The yield is around 70-80%, and the reaction is conducted under anhydrous conditions to avoid hydrolysis.

What industries use 2-Chloro-3-hydroxy-4-quinolinecarboxylic acid (CAS: 847547-91-5)?

2-Chloro-3-hydroxy-4-quinolinecarboxylic acid finds applications in the pharmaceutical industry as an intermediate in drug synthesis. It is also used in the development of sensors and as a precursor in the synthesis of other quinoline derivatives. Its use in polymers and semiconductors is limited but under investigation for specific applications.

What precautions should be taken when handling 2-Chloro-3-hydroxy-4-quinolinecarboxylic acid (CAS: 847547-91-5)?

When handling 2-Chloro-3-hydroxy-4-quinolinecarboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood to avoid inhalation. Spills should be cleaned up using an appropriate solvent, and the area should be thoroughly washed. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.