Compound Q&A
How is 2-Chloro-3-hydroxy-4-quinolinecarboxylic acid (CAS: 847547-91-5) typically synthesized?
Answer
2-Chloro-3-hydroxy-4-quinolinecarboxylic acid is typically synthesized through the chlorination of a hydroxyquinoline derivative followed by carboxylation. Commonly used reagents include phosphorous pentachloride for chlorination and chloroacetic anhydride for carboxylation. The yield is around 70-80%, and the reaction is conducted under anhydrous conditions to avoid hydrolysis.
About
CAS No
847547-91-5
English Name
2-Chloro-3-hydroxy-4-quinolinecarboxylic acid
Molecular Formula
C10H6ClNO3
Molecular Weight
223.61 g/mol
SMILES
c1ccc2c(c1)c(c(c(n2)Cl)O)C(=O)O
InChIKey
RPGQCGYSROBDNQ-UHFFFAOYSA-N
Last Updated: 2026-01-01 15:34
