1-(5-Nitro-2-pyridinyl)piperazine

Basic Information

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CAS Number

82205-58-1

Molecular Formula

C9H12N4O2

Molecular Weight

208.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

418.1°C at 760 mmHg

SMILES

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C1CN(CCN1)C2=NC=C(C=C2)[N+](=O)[O-]

InChI

InChI=1S/C9H12N4O2/c14-13(15)8-1-2-9(11-7-8)12-5-3-10-4-6-12/h1-2,7,10H,3-6H2

InChIKey

YEPRCPIKTUGVHG-UHFFFAOYSA-N

LogP

1.31640

Complexity

225

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SCHEMBL670110
SR-01000253068
DTXSID50387878
1-(5-Nitro-pyridin-2-yl)-piperazine
MFCD00053059
AS-871/43475564
1-(5-Nitropyridin-2-yl)piperazine, AldrichCPR
YEPRCPIKTUGVHG-UHFFFAOYSA-N
82205-58-1
SR-01000253068-1
AKOS000123123
AM20070098
DS-0028
5-Nitro-2-piperazinyl-pyridine
BB 0237425
EN300-41962
PS-3972
1-(5-nitropyridin-2-yl)piperazine
CS-0148490
1-(5-nitro-2-pyridinyl)-piperazine
4-(5-nitro-2-pyridinyl)piperazine
1-(5-nitro-2-pyridinyl)piperazine
Z199418004
FT-0659481
1-(5-Nitropyridin-2-yl)piperazine
1-(5-NITRO-PYRIDIN-2-YL)-PIPERAZINE
Piperazine,1-(5-nitro-2-pyridyl)- (6CI)
4-(5-Nitropyridin-2-yl)piperazine
5-Nitro-2-piperazinylpyridine
(5-nitro-2-pyridyl)piperazine
1-(5-nitro-2-pyridyl)piperazine

MDL Number

MFCD00053059

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-(5-Nitro-2-pyridinyl)piperazine (CAS: 82205-58-1)?

1-(5-Nitro-2-pyridinyl)piperazine is a crystalline solid with a molecular weight of approximately 231.13 g/mol. It has a solubility of about 10 mg/mL in water and is soluble in organic solvents such as methanol. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It exhibits good stability under normal conditions but requires storage in a cool, dry place away from moisture.

How is 1-(5-Nitro-2-pyridinyl)piperazine (CAS: 82205-58-1) typically synthesized?

1-(5-Nitro-2-pyridinyl)piperazine is often synthesized through a multistep process involving the reaction of piperazine with 5-nitropyridine in the presence of a base such as potassium carbonate. The yield is typically around 70-80%, with good selectivity to the desired product. The exact method can vary depending on the specific laboratory and equipment available.

What industries use 1-(5-Nitro-2-pyridinyl)piperazine (CAS: 82205-58-1)?

1-(5-Nitro-2-pyridinyl)piperazine is primarily used in the pharmaceutical industry as a precursor for drug development. It is also utilized in the synthesis of polymers with specific properties and in the production of sensors for detecting various analytes. Additionally, it has applications in the semiconductor industry for its role in material preparation.

What precautions should be taken when handling 1-(5-Nitro-2-pyridinyl)piperazine (CAS: 82205-58-1)?

When handling 1-(5-Nitro-2-pyridinyl)piperazine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.