2,3,6-Trichloro-4-(trifluoromethyl)pyridine | CAS No. 81565-20-0
2,3,6-Trichloro-4-(trifluoromethyl)pyridine
Basic Information
CAS Number
81565-20-0
Molecular Formula
C6HCl3F3N
Molecular Weight
250.43 g/mol
AD
Basic Physical Properties
Boiling Point
232.5±35.0 ºC (760 Torr),
Density
1.647±0.06 g/cm3 (20 ºC 760 Torr),
Flash Point
94.4±25.9 ºC,
Synonyms & References
English
- AMY17384
- CS-0343161
- KCMZCZXPLOZOGG-UHFFFAOYSA-N
- SCHEMBL1787999
- F75283
- 81565-20-0
- 2,3,6-TRICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE
- 2,3,6-Trichloro-4-trifluoromethyl-pyridine
- AKOS015891913
- 2,3,6-Trichloro-4-(trifluoromethyl)pyridine
MDL Number
MFCD17676605
FAQ
What are the physical and chemical properties of 2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0)?
2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0) is a crystalline solid with a molecular weight of approximately 320.04 g/mol. It has low water solubility but is soluble in organic solvents like dichloromethane and acetonitrile. Chemically, it is moderately reactive, particularly with nucleophiles, and is a potent electron-withdrawing group.
How is 2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0) typically synthesized?
2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0) is typically synthesized via electrophilic aromatic substitution reactions involving 4-chloro-2,3,6-trimethylpyridine and trifluoroacetyl chloride. The reaction is carried out in the presence of a Lewis acid catalyst, such as aluminum chloride, to promote the electrophilic reactivity of the trifluoroacetyl chloride.
What industries use 2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0)?
2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0) is primarily used in the pharmaceutical industry for the synthesis of certain drugs and in the semiconductor industry for doping materials. It is also used in the production of certain sensors and as a precursor in polymer chemistry.
What precautions should be taken when handling 2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0)?
When handling 2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0), use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with caution using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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