2,3,6-Trichloro-4-(trifluoromethyl)pyridine(CAS: 81565-20-0)

2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0) is a crystalline solid with a molecular weight of approximately 320.04 g/mol. It has low water solubility but is soluble in organic solvents like dichloromethane and acetonitrile. Chemically, it is moderately reactive, particularly with nucleophiles, and is a potent electron-withdrawing group.

2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0) is typically synthesized via electrophilic aromatic substitution reactions involving 4-chloro-2,3,6-trimethylpyridine and trifluoroacetyl chloride. The reaction is carried out in the presence of a Lewis acid catalyst, such as aluminum chloride, to promote the electrophilic reactivity of the trifluoroacetyl chloride.

2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0) is primarily used in the pharmaceutical industry for the synthesis of certain drugs and in the semiconductor industry for doping materials. It is also used in the production of certain sensors and as a precursor in polymer chemistry.

When handling 2,3,6-Trichloro-4-(trifluoromethyl)pyridine (CAS: 81565-20-0), use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with caution using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.