Amorolfine | CAS No. 78613-35-1

Amorolfine

Basic Information

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CAS Number

78613-35-1

Molecular Formula

C21H35NO

Molecular Weight

317.52 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

bp0.1 120°

SMILES

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CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1

InChI

InChI=1S/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+

InChIKey

MQHLMHIZUIDKOO-AYHJJNSGSA-N

LogP

4.662000000000004

Topological Polar Surface Area

12.47 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

336

Synonyms & References

English

Amorolfine
Amorolfine HCl
SYLIMARIN
Fradafi
Fradafiban
Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, (2R,6S)-rel-
(+/-)-cis-2,6-dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine
000
4-(3-(4-(1,1-Dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine
amorolfin
cis-4-{3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propyl}-2,6-dimethylmorpholine
Loceryl
Ro 14-4767
Ro-l4-4767

MDL Number

MFCD00865597

FAQ

What are the physical and chemical properties of Amorolfine (CAS: 78613-35-1)?

Amorolfine (CAS: 78613-35-1) is a crystalline compound with a molecular weight of approximately 273.28 g/mol. It has limited water solubility and is sparingly soluble in organic solvents such as ethanol and acetone. Amorolfine is relatively stable under normal storage conditions but reacts with strong bases and reducing agents. It is primarily used as a topical antifungal agent in dermatological applications.

How is Amorolfine (CAS: 78613-35-1) typically synthesized?

Amorolfine (CAS: 78613-35-1) is typically synthesized via a multistep process, starting from 2-(3-bromophenyl)propanoic acid. The synthesis involves bromination, reduction, and coupling reactions. Commonly used catalysts include palladium-based catalysts, and the overall process yields up to 80% of Amorolfine, with good selectivity and minimal side products.

What industries use Amorolfine (CAS: 78613-35-1)?

Amorolfine (CAS: 78613-35-1) is primarily used in the pharmaceutical industry, particularly in dermatological applications as a topical antifungal agent. It is also used in research for studying fungal infections and developing antifungal therapies.

What precautions should be taken when handling Amorolfine (CAS: 78613-35-1)?

When handling Amorolfine (CAS: 78613-35-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Handle in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up according to standard laboratory procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.