Amorolfine(CAS: 78613-35-1)

Amorolfine (CAS: 78613-35-1) is a crystalline compound with a molecular weight of approximately 273.28 g/mol. It has limited water solubility and is sparingly soluble in organic solvents such as ethanol and acetone. Amorolfine is relatively stable under normal storage conditions but reacts with strong bases and reducing agents. It is primarily used as a topical antifungal agent in dermatological applications.

Amorolfine (CAS: 78613-35-1) is typically synthesized via a multistep process, starting from 2-(3-bromophenyl)propanoic acid. The synthesis involves bromination, reduction, and coupling reactions. Commonly used catalysts include palladium-based catalysts, and the overall process yields up to 80% of Amorolfine, with good selectivity and minimal side products.

Amorolfine (CAS: 78613-35-1) is primarily used in the pharmaceutical industry, particularly in dermatological applications as a topical antifungal agent. It is also used in research for studying fungal infections and developing antifungal therapies.

When handling Amorolfine (CAS: 78613-35-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Handle in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up according to standard laboratory procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.