(2-Chlorophenyl)methanesulfonyl chloride

Basic Information

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CAS Number

77421-13-7

Molecular Formula

C7H6Cl2O2S

Molecular Weight

225.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

59-63 °C

SMILES

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C1=CC=C(C(=C1)CS(=O)(=O)Cl)Cl

InChI

InChI=1S/C7H6Cl2O2S/c8-7-4-2-1-3-6(7)5-12(9,10)11/h1-4H,5H2

InChIKey

CHPZYFXSICSCNY-UHFFFAOYSA-N

LogP

2.4086

Topological Polar Surface Area

34.14 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

232

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

A839090
[(2-chlorophenyl)-methyl]sulfonyl chloride
(2-Chlorophenyl)methanesulfonylchloride
[(2-chlorophenyl)methyl]sulfonyl chloride
CHPZYFXSICSCNY-UHFFFAOYSA-N
77421-13-7
MFCD04116369
(2-chlorophenyl)methane-sulfonyl chloride
(2-Chloro-phenyl)-methanesulfonyl chloride
(2-Chlorophenyl)methanesulfonyl chloride
2-Chlorobenzylsulfonyl chloride, 97%
FT-0604620
GEO-00767
F3308-2772
2-Chlorobenzylsulfonyl chloride
AKOS000130183
(2-chlorophenyl)methanesulfonyl chloride;2-Chlorobenzylsulfonyl Chloride
FS-5548
(2-chloro-phenyl)methanesulfonyl chloride
DTXSID00374036
EN300-65586
(2-CHLORO-PHENYL)-METHANESULFONYLCHLORIDE
(2-chlorophenyl)-METHANESULFONYL CHLORIDE
BB 0254200
SCHEMBL5963
S26
S30
S45
(2-Chlorophenyl)methanesulfonyl chloride, 2-Chloro-α-toluenesulfonyl chloride, 2-Chlorobenzenemethanesulfonyl chloride
(2-CHLOROPHENYL)-METHANESULFONYL CHLORIDE
Benzenemethanesulfonylchloride, 2-chloro-

MDL Number

MFCD04116369

FAQ

What are the physical and chemical properties of (2-Chlorophenyl)methanesulfonyl chloride (CAS: 77421-13-7)?

(2-Chlorophenyl)methanesulfonyl chloride is a white crystalline solid with a molecular weight of approximately 220.59 g/mol. It has low water solubility but good solubility in organic solvents like dichloromethane and acetone. This compound is highly reactive, particularly with primary amines and alcohols. It is used in organic synthesis for its sulfonating properties.

How is (2-Chlorophenyl)methanesulfonyl chloride (CAS: 77421-13-7) typically synthesized?

(2-Chlorophenyl)methanesulfonyl chloride is usually synthesized by the reaction of 2-chlorophenylmethanol with thionyl chloride in the presence of an appropriate solvent like dichloromethane. This process requires careful temperature control and is often catalyzed to improve yield and selectivity.

What industries use (2-Chlorophenyl)methanesulfonyl chloride (CAS: 77421-13-7)?

(2-Chlorophenyl)methanesulfonyl chloride is used in the pharmaceutical industry for synthesizing intermediates, in the polymer industry for modifying polymers, and in the semiconductor industry for fabricating electronic components. It is also utilized in the sensor industry for developing gas sensors.

What precautions should be taken when handling (2-Chlorophenyl)methanesulfonyl chloride (CAS: 77421-13-7)?

When handling (2-Chlorophenyl)methanesulfonyl chloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood to minimize exposure to vapor. Spills should be handled by professional personnel with appropriate safety measures in place, and the substance should be stored in a cool, dry place away from heat sources. Safety data sheets (SDS) should be consulted for detailed handling instructions.