Linagliptin Impurity G

Basic Information

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CAS Number

668270-11-9

Molecular Formula

C25H28N8O2

Molecular Weight

30.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

InChI

InChI=1S/C2H6/c1-2/h1-2H3

InChIKey

OTMSDBZUPAUEDD-UHFFFAOYSA-N

LogP

1.0262

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

885

Synonyms & References

English

1H-Purine-2,6-dione,8-[(3S)-3-amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-
(S)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
(S)-8-(3-Aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
LINAGLIPTIN, (S)-
(S)-8-(3-Aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione (Linagliptin Impurity)
8-[(3S)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Z3217405471
Linagliptin Impurity G
8-[(3S)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
CS-0255299
EN300-2008997
Linagliptin S isomer
1H-Purine-2,6-dione, 8-((3S)-3-amino-1-piperidinyl)-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)-
668270-11-9
2U6HE75USV
A899869
1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(S)-amino-piperidin-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine;
8-[(3S)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
SCHEMBL637238
F19281
(S)-Linagliptin
UNII-2U6HE75USV
Linagliptin Impurity 10 (S-Isomer)

MDL Number

MFCD28386802

FAQ

What are the physical and chemical properties of Linagliptin Impurity G (CAS: 668270-11-9)?

Linagliptin Impurity G is a white to off-white crystalline solid with a molecular weight of approximately 364.34 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. The impurity is less reactive than the parent compound, Linagliptin, but can still undergo similar chemical reactions under certain conditions, such as acidic or basic catalysis.

How is Linagliptin Impurity G (CAS: 668270-11-9) typically synthesized?

Linagliptin Impurity G is typically synthesized through the modification of the parent compound, Linagliptin, using a series of chemical reactions. This involves selective functional group transformations and can utilize different catalysts to achieve the desired impurity profile. The synthesis yields moderate to high purity depending on the specific conditions and methods employed.

What industries use Linagliptin Impurity G (CAS: 668270-11-9)?

Linagliptin Impurity G is primarily used in the pharmaceutical industry as a quality control and impurity reference for Linagliptin, a DPP-4 inhibitor used in the treatment of type 2 diabetes. It is not widely used in other industries such as polymers, sensors, or semiconductors.

What precautions should be taken when handling Linagliptin Impurity G (CAS: 668270-11-9)?

Handling Linagliptin Impurity G requires the use of personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. It should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In the event of a spill, it should be cleaned up using appropriate safety procedures and materials. For more detailed safety information, refer to the Safety Data Sheet (SDS) for Linagliptin Impurity G.