Methyl 6-chloro-2-pyridinecarboxylate

Basic Information

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CAS Number

6636-55-1

Molecular Formula

C7H6ClNO2

Molecular Weight

171.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

93.0 to 97.0 deg-C

Boiling Point

275.832°C at 760 mmHg

Density

1.295

Water Solubility

Slightly soluble in water.

Flash Point

120.619℃

Refractive Index

1.531

SMILES

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COC(=O)C1=NC(=CC=C1)Cl

InChI

InChI=1S/C7H6ClNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3

InChIKey

TWUXBVMXSBEKHA-UHFFFAOYSA-N

LogP

1.5215999999999998

Topological Polar Surface Area

39.19 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

151

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AKOS000269663
6-Chloro-2-picolinic acid methyl ester
BCP21041
6-chloro-pyridine-2-carboxylic acid methyl ester
MB00777
CL0084
6-Chloro-2-picolinic acid, methyl ester
6-Chloropicolinic Acid Methyl Ester
HMS1395E12
methyl 6-chloropyridine-2-carboxylate
MFCD00155391
MS-3561
J-522550
NSC51592
DTXSID30287569
Methyl 6-chloro-2-pyridinecarboxylate
A8954
Methyl 6-chloropicolinate
AC-3382
CS-W002452
Enamine_000452
Methyl 6-chloropicolinate;Methyl 6-chloro-2-pyridinecarboxylate
FT-0659118
6-chloro-2-pyridinecarboxylic acid, methyl ester
6-CHLORO-2-PYRIDINECARBOXYLIC ACID METHYL ESTER
Z56771184
SY007550
ISOBUTYLHYDROGENMETHYLPHOSPHONATE
EN300-124201
Methyl 6-chloro-pyridine-2-carboxylate
M2640

MDL Number

MFCD00155391

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1)?

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) is a white crystalline solid. It has a molecular weight of approximately 161.02 g/mol. The compound is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. It is relatively stable under normal conditions but can react with strong bases to form pyridine derivatives. Its reactivity is typical of carboxylic acid derivatives.

How is Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) typically synthesized?

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) is typically synthesized via a Grignard reaction or a Friedel-Crafts acylation. In a Grignard reaction, 2-chloropyridine is reacted with methyl magnesium bromide to form the Grignard reagent, which is then reacted with acetyl chloride to give the desired product. In a Friedel-Crafts acylation, 2-chloropyridine is acylated using acetyl chloride in the presence of a Lewis acid like aluminum chloride.

What industries use Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1)?

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) is used in various industries, including pharmaceuticals and fine chemicals. It serves as a valuable intermediate in the synthesis of other compounds, particularly in the development of new drugs and agrochemicals. Its use in polymer synthesis and as a precursor in the production of functional materials is also noted.

What precautions should be taken when handling Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1)?

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) should be handled with caution due to its potential for skin and eye irritation. Use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Store in a cool, dry place away from sources of heat and ignition. In case of spill, neutralize with an appropriate agent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.