Methyl 6-chloro-2-pyridinecarboxylate(CAS: 6636-55-1)

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) is a white crystalline solid. It has a molecular weight of approximately 161.02 g/mol. The compound is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. It is relatively stable under normal conditions but can react with strong bases to form pyridine derivatives. Its reactivity is typical of carboxylic acid derivatives.

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) is typically synthesized via a Grignard reaction or a Friedel-Crafts acylation. In a Grignard reaction, 2-chloropyridine is reacted with methyl magnesium bromide to form the Grignard reagent, which is then reacted with acetyl chloride to give the desired product. In a Friedel-Crafts acylation, 2-chloropyridine is acylated using acetyl chloride in the presence of a Lewis acid like aluminum chloride.

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) is used in various industries, including pharmaceuticals and fine chemicals. It serves as a valuable intermediate in the synthesis of other compounds, particularly in the development of new drugs and agrochemicals. Its use in polymer synthesis and as a precursor in the production of functional materials is also noted.

Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) should be handled with caution due to its potential for skin and eye irritation. Use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Store in a cool, dry place away from sources of heat and ignition. In case of spill, neutralize with an appropriate agent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.