Compound Q&A
How is Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) typically synthesized?
Answer
Methyl 6-chloro-2-pyridinecarboxylate (CAS: 6636-55-1) is typically synthesized via a Grignard reaction or a Friedel-Crafts acylation. In a Grignard reaction, 2-chloropyridine is reacted with methyl magnesium bromide to form the Grignard reagent, which is then reacted with acetyl chloride to give the desired product. In a Friedel-Crafts acylation, 2-chloropyridine is acylated using acetyl chloride in the presence of a Lewis acid like aluminum chloride.
About
CAS No
6636-55-1
English Name
Methyl 6-chloro-2-pyridinecarboxylate
Molecular Formula
C7H6ClNO2
Molecular Weight
171.58 g/mol
SMILES
COC(=O)C1=NC(=CC=C1)Cl
InChIKey
TWUXBVMXSBEKHA-UHFFFAOYSA-N
Last Updated: 2025-10-01 13:51
