4,5-Dichloro-3-nitro-2-pyridinamine

Basic Information

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CAS Number

662116-67-8

Molecular Formula

C5H3Cl2N3O2

Molecular Weight

208 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

SMILES

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Nc1ncc(Cl)c(Cl)c1[N+](=O)[O-]

InChI

InChI=1S/C5H3Cl2N3O2/c6-2-1-9-5(8)4(3(2)7)10(11)12/h1H,(H2,8,9)

InChIKey

KYVDKOZOAOAFDC-UHFFFAOYSA-N

LogP

2.33210

Complexity

186

Synonyms & References

English

4,5-Dichloro-3-nitropyridin-2-amine
2-Amino-4,5-dichloro-3-nitropyridine
2-amino-3-nitro-4,5-dichloropyridine
4,5-dichloro-3-nitropyridin-2-ylamine
RW3676
KYVDKOZOAOAFDC-UHFFFAOYSA-N
0169AC
PB21362
2-amino-4,5-dichloro-3-nitro-pyridine
4,5-Dichloro-3-nitro-pyridin-2-ylamine
AB0095270

MDL Number

MFCD15143363

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4,5-Dichloro-3-nitro-2-pyridinamine (CAS: 6621116-67-8)?

4,5-Dichloro-3-nitro-2-pyridinamine is a crystalline solid with a molecular weight of approximately 240.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive due to the presence of electron-withdrawing nitro and chloro substituents, making it susceptible to nucleophilic substitution reactions.

How is 4,5-Dichloro-3-nitro-2-pyridinamine (CAS: 662116-67-8) typically synthesized?

4,5-Dichloro-3-nitro-2-pyridinamine can be synthesized through a multi-step process involving the nitration of 2-pyridinamine followed by chlorination. Commonly, the nitration is performed using nitric acid and sulfuric acid as a catalyst, yielding a nitro group, which is then chlorinated with thionyl chloride to introduce the chloro substituents. The overall yield is around 70%.

What industries use 4,5-Dichloro-3-nitro-2-pyridinamine (CAS: 662116-67-8)?

4,5-Dichloro-3-nitro-2-pyridinamine finds applications in the pharmaceutical industry, where it serves as a precursor for drug synthesis. It is also used in the production of certain dyes and pigments, and in the development of chemical sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 4,5-Dichloro-3-nitro-2-pyridinamine (CAS: 662116-67-8)?

Proper handling of 4,5-Dichloro-3-nitro-2-pyridinamine requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to toxic fumes. Spills should be contained and cleaned up using appropriate absorbent materials, and the site should be rinsed thoroughly. Always consult the safety data sheet (SDS) for detailed handling and emergency procedures.