4,5-Dichloro-3-nitro-2-pyridinamine(CAS: 662116-67-8)

4,5-Dichloro-3-nitro-2-pyridinamine is a crystalline solid with a molecular weight of approximately 240.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive due to the presence of electron-withdrawing nitro and chloro substituents, making it susceptible to nucleophilic substitution reactions.

4,5-Dichloro-3-nitro-2-pyridinamine can be synthesized through a multi-step process involving the nitration of 2-pyridinamine followed by chlorination. Commonly, the nitration is performed using nitric acid and sulfuric acid as a catalyst, yielding a nitro group, which is then chlorinated with thionyl chloride to introduce the chloro substituents. The overall yield is around 70%.

4,5-Dichloro-3-nitro-2-pyridinamine finds applications in the pharmaceutical industry, where it serves as a precursor for drug synthesis. It is also used in the production of certain dyes and pigments, and in the development of chemical sensors and semiconductors due to its unique electronic properties.

Proper handling of 4,5-Dichloro-3-nitro-2-pyridinamine requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to toxic fumes. Spills should be contained and cleaned up using appropriate absorbent materials, and the site should be rinsed thoroughly. Always consult the safety data sheet (SDS) for detailed handling and emergency procedures.