7-Hydroxyquinoline-3-carboxylic acid

Basic Information

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CAS Number

659730-27-5

Molecular Formula

C10H7NO3

Molecular Weight

189.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C1=CC(=CC2=NC=C(C=C21)C(=O)O)O

InChI

InChI=1S/C10H7NO3/c12-8-2-1-6-3-7(10(13)14)5-11-9(6)4-8/h1-5,12H,(H,13,14)

InChIKey

RFVSBXGQVAGYJQ-UHFFFAOYSA-N

LogP

1.6385999999999998

Topological Polar Surface Area

70.42 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

231

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

7-hydroxyquinoline-3-carboxylic acid
7-oxo-1H-quinoline-3-carboxylic acid
AK164656
7-hydroxyquinoline-3-carboxylic acid HBr
7-Hydroxy-3-quinolinecarboxylate
RFVSBXGQVAGYJQ-UHFFFAOYSA-N
7-hydroxy 3-quinolinecarboxylic acid
FCH1173087
3-Quinolinecarboxylic acid, 7-hydroxy-
AB0049227
7-Oxo-1,7-dihydroquinoline-3-carboxylic acid
Z2832012391
DTXSID00631111
659730-27-5
EN300-370750
7-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
DA-03848
SCHEMBL1353291
SB68554
Z1255445848
CS-0043086
DS-8633
MFCD18417142
AMY26426
7-HYDROXYQUINOLINE-3-CARBOXYLICACID
AKOS025146532

MDL Number

MFCD18417142

FAQ

What are the physical and chemical properties of 7-Hydroxyquinoline-3-carboxylic acid (CAS: 659730-27-5)?

7-Hydroxyquinoline-3-carboxylic acid is a crystalline solid with a molecular weight of approximately 206.18 g/mol. It has a solubility of about 2.8 g/L in water at 20°C and is slightly soluble in ethanol and acetone. Chemically, it is reactive towards bases and can form salts with various cations. It exhibits weak acidity due to the carboxylic acid group.

How is 7-Hydroxyquinoline-3-carboxylic acid (CAS: 659730-27-5) typically synthesized?

7-Hydroxyquinoline-3-carboxylic acid can be synthesized through the condensation of 4-hydroxyquinoline with acetic anhydride in the presence of a catalytic amount of pyridine. The reaction yields a 90% pure product with good selectivity. The process is carried out under mild conditions and provides a straightforward method for obtaining the compound.

What industries use 7-Hydroxyquinoline-3-carboxylic acid (CAS: 659730-27-5)?

7-Hydroxyquinoline-3-carboxylic acid is used in various industries such as pharmaceuticals, where it serves as a precursor for drug development, and in the production of sensors and semiconductors. It is also explored in the synthesis of dyes and pigments due to its unique chemical properties.

What precautions should be taken when handling 7-Hydroxyquinoline-3-carboxylic acid (CAS: 659730-27-5)?

When handling 7-Hydroxyquinoline-3-carboxylic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and lab coats. Store it in a well-ventilated area and use a fume hood during operations. In case of a spill, immediately contain it with appropriate materials and follow the safety data sheet (SDS) for disposal. Always consult the SDS for detailed safety guidelines.