7-Hydroxyquinoline-3-carboxylic acid(CAS: 659730-27-5)

7-Hydroxyquinoline-3-carboxylic acid is a crystalline solid with a molecular weight of approximately 206.18 g/mol. It has a solubility of about 2.8 g/L in water at 20°C and is slightly soluble in ethanol and acetone. Chemically, it is reactive towards bases and can form salts with various cations. It exhibits weak acidity due to the carboxylic acid group.

7-Hydroxyquinoline-3-carboxylic acid can be synthesized through the condensation of 4-hydroxyquinoline with acetic anhydride in the presence of a catalytic amount of pyridine. The reaction yields a 90% pure product with good selectivity. The process is carried out under mild conditions and provides a straightforward method for obtaining the compound.

7-Hydroxyquinoline-3-carboxylic acid is used in various industries such as pharmaceuticals, where it serves as a precursor for drug development, and in the production of sensors and semiconductors. It is also explored in the synthesis of dyes and pigments due to its unique chemical properties.

When handling 7-Hydroxyquinoline-3-carboxylic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and lab coats. Store it in a well-ventilated area and use a fume hood during operations. In case of a spill, immediately contain it with appropriate materials and follow the safety data sheet (SDS) for disposal. Always consult the SDS for detailed safety guidelines.