4-Chloro-2-nitropyridine

Basic Information

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CAS Number

65370-42-5

Molecular Formula

C5H3ClN2O2

Molecular Weight

158.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Boiling Point

267.6°C at 760 mmHg

SMILES

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C1=CN=C(C=C1Cl)[N+](=O)[O-]

InChI

InChI=1S/C5H3ClN2O2/c6-4-1-2-7-5(3-4)8(9)10/h1-3H

InChIKey

YPKBJRKFGYVURL-UHFFFAOYSA-N

LogP

2.16640

Complexity

136

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SB52435
AS-18479
SY038052
MFCD04114167
AKOS006291856
AMY23028
Pyridine, 4-chloro-2-nitro-
A806164
CS-W004881
DTXSID70376507
AC-25194
A15735
65370-42-5
4-chloro-2-nitropyridine
BCP10977
4-chloro-2-nitro-pyridine
4-chloranyl-2-nitro-pyridine
YPKBJRKFGYVURL-UHFFFAOYSA-N
EN300-316378
FT-0646439
SCHEMBL826540
4-Chloro-2-nitropyridine
2-Nitro-4-chlorpyridin
Pyridine,4-chloro-2-nitro
PubChem6664
FCH848846
VP13481
OR345390
AB0026080
ST2411292
AX8095820

MDL Number

MFCD04114167

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Chloro-2-nitropyridine (CAS: 65370-42-5)?

4-Chloro-2-nitropyridine is a crystalline solid with a molecular weight of approximately 177.58 g/mol. It is slightly soluble in water but readily soluble in organic solvents such as ethanol and acetone. Chemically, it exhibits basic properties due to the nitro group and is prone to hydrolysis under basic conditions. It is also reactive towards nucleophiles and can undergo substitution reactions.

How is 4-Chloro-2-nitropyridine (CAS: 65370-42-5) typically synthesized?

4-Chloro-2-nitropyridine is typically synthesized via the nitration of 4-chloropyridine. This process involves the use of nitric acid and sulfuric acid as the nitrating agent. The yield can vary depending on the reaction conditions, but the process is generally straightforward and can achieve high selectivity and yield under optimal conditions.

What industries use 4-Chloro-2-nitropyridine (CAS: 65370-42-5)?

4-Chloro-2-nitropyridine is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also utilized in the polymer industry for the development of new materials and in the sensor industry for its sensitivity to certain chemical species. Additionally, it has applications in the semiconductor industry for its use in thin film deposition processes.

What precautions should be taken when handling 4-Chloro-2-nitropyridine (CAS: 65370-42-5)?

Proper handling of 4-Chloro-2-nitropyridine requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up using appropriate materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.