![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
Methyl 4-bromo-5-cyano-2-thiophenecarboxylate | CAS No. 648412-60-6
Methyl 4-bromo-5-cyano-2-thiophenecarboxylate
Basic Information
CAS Number
648412-60-6
Molecular Formula
C7H4BrNO2S
Molecular Weight
246.08 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- F83560
- Methyl4-bromo-5-cyanothiophene-2-carboxylate
- CS-0301888
- 648412-60-6
- Methyl 4-bromo-5-cyanothiophene-2-carboxylate
- CLUNERGOTORYPP-UHFFFAOYSA-N
- FT-0759951
- Z1551958723
- EN300-5235826
- DTXSID90739115
- SCHEMBL3882941
- 2-Thiophenecarboxylic acid, 4-bromo-5-cyano-, methyl ester
- AMY10029
MDL Number
MFCD22200340
Customs Code
2934999090
FAQ
What are the physical and chemical properties of Methyl 4-bromo-5-cyano-2-thiophenecarboxylate (CAS: 648412-60-6)?
Methyl 4-bromo-5-cyano-2-thiophenecarboxylate is a crystalline compound with a molecular weight of approximately 278.04 g/mol. It has a low solubility in water but is soluble in common organic solvents like dichloromethane and acetone. Chemically, it is highly reactive and prone to nucleophilic substitution reactions, making it a versatile intermediate in organic synthesis.
How is Methyl 4-bromo-5-cyano-2-thiophenecarboxylate (CAS: 648412-60-6) typically synthesized?
Methyl 4-bromo-5-cyano-2-thiophenecarboxylate is typically synthesized by reacting methyl thiophene-2-carboxylate with acetonitrile in the presence of a catalytic amount of a Lewis acid such as aluminum chloride. The reaction proceeds under reflux conditions, and the product is purified by recrystallization from a suitable solvent.
What industries use Methyl 4-bromo-5-cyano-2-thiophenecarboxylate (CAS: 648412-60-6)?
Methyl 4-bromo-5-cyano-2-thiophenecarboxylate is used in the pharmaceutical and fine chemical industries due to its reactivity and utility as an intermediate. It is also relevant in polymer chemistry for the synthesis of advanced materials and in sensor technology for specific chemical detection applications.
What precautions should be taken when handling Methyl 4-bromo-5-cyano-2-thiophenecarboxylate (CAS: 648412-60-6)?
Proper precautions include handling Methyl 4-bromo-5-cyano-2-thiophenecarboxylate in a fume hood to avoid exposure to its vapors. Wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store the compound in a cool, well-ventilated area away from heat and ignition sources. In case of a spill, neutralize the material with a base if necessary, and dispose of it according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed instructions.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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