Methyl 4-bromo-5-cyano-2-thiophenecarboxylate(CAS: 648412-60-6)

Methyl 4-bromo-5-cyano-2-thiophenecarboxylate is a crystalline compound with a molecular weight of approximately 278.04 g/mol. It has a low solubility in water but is soluble in common organic solvents like dichloromethane and acetone. Chemically, it is highly reactive and prone to nucleophilic substitution reactions, making it a versatile intermediate in organic synthesis.

Methyl 4-bromo-5-cyano-2-thiophenecarboxylate is typically synthesized by reacting methyl thiophene-2-carboxylate with acetonitrile in the presence of a catalytic amount of a Lewis acid such as aluminum chloride. The reaction proceeds under reflux conditions, and the product is purified by recrystallization from a suitable solvent.

Methyl 4-bromo-5-cyano-2-thiophenecarboxylate is used in the pharmaceutical and fine chemical industries due to its reactivity and utility as an intermediate. It is also relevant in polymer chemistry for the synthesis of advanced materials and in sensor technology for specific chemical detection applications.

Proper precautions include handling Methyl 4-bromo-5-cyano-2-thiophenecarboxylate in a fume hood to avoid exposure to its vapors. Wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store the compound in a cool, well-ventilated area away from heat and ignition sources. In case of a spill, neutralize the material with a base if necessary, and dispose of it according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed instructions.