6-Chloro-2-methyl-3-nitropyridine

Basic Information

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CAS Number

56057-19-3

Molecular Formula

C6H5ClN2O2

Molecular Weight

172.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

70.0 to 74.0 deg-C

Boiling Point

281.7°C at 760 mmHg

Density

1.5610 (rough estimate)

Flash Point

124.2℃

Refractive Index

1.5500 (estimate)

SMILES

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CC1=NC(=C(C=C1)[N+](=O)[O-])Cl

InChI

InChI=1S/C6H5ClN2O2/c1-4-5(9(10)11)2-3-6(7)8-4/h2-3H,1H3

InChIKey

GHSRMSJVYMITDX-UHFFFAOYSA-N

LogP

2.47480

Complexity

159

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

AKOS005145731
EN300-104370
PS-4678
AC-9491
2-chloro-6-methyl-3-nitropyridine
AC-5407
CS-0007518
BCP22156
56057-19-3
2-Chloro-3-nitro-6-picoline (2-Chloro-6-methyl-3-nitropyridine)
DTXSID90361475
A8074
C2594
2-Chloro-3-nitro-6-picoline
2-Chloro-3-Nitro-6-Methyl pyridine
Pyridine, 2-chloro-6-methyl-3-nitro-
UIEVSGOVFXWCIK-UHFFFAOYSA-N
MFCD03085820
CL0071
2-Chloro-3-nitro-6-methylpyridine
AM20070081
FT-0601487
SCHEMBL136263
6-Chloro-5-nitro-2-picoline
2-chloro-5-methyl-3-nitropyridine
6-Chloro-2-methyl-5-nitropyridine
2-Chloro-6-methyl-3-nitropyridine
2-chloro-6-methyl-3-nitro-pyridine

MDL Number

MFCD03085820

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-Chloro-2-methyl-3-nitropyridine (CAS: 56057-19-3)?

6-Chloro-2-methyl-3-nitropyridine is a crystalline solid with a molecular weight of approximately 199.01 g/mol. Its solubility in water is low, typically less than 1 g/L at 25°C. It is moderately reactive, particularly towards reducing agents and bases. The compound is highly soluble in organic solvents like dichloromethane and acetonitrile.

How is 6-Chloro-2-methyl-3-nitropyridine (CAS: 56057-19-3) typically synthesized?

6-Chloro-2-methyl-3-nitropyridine is commonly synthesized through electrophilic aromatic substitution reactions. A typical method involves the nitration of 2-methylpyridine followed by chlorination. The reaction proceeds under mild conditions using concentrated sulfuric acid as a catalyst and nitric acid as the nitrating agent. Chlorine gas is then introduced to the intermediate product to achieve the final structure.

What industries use 6-Chloro-2-methyl-3-nitropyridine (CAS: 56057-19-3)?

6-Chloro-2-methyl-3-nitropyridine finds applications primarily in the pharmaceutical industry, where it serves as a precursor to various drug candidates. It is also used in the synthesis of certain agrochemicals and sensors due to its unique reactivity and functional groups. Its use in semiconductor and polymer industries is less common but not entirely absent.

What precautions should be taken when handling 6-Chloro-2-methyl-3-nitropyridine (CAS: 56057-19-3)?

When handling 6-Chloro-2-methyl-3-nitropyridine, it is essential to wear appropriate personal protective equipment (PPE), including safety glasses, gloves, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood due to its potential volatility and reactivity. Spills should be carefully cleaned up using appropriate absorbents, and the area should be thoroughly ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.