2'-O-tert-Butyldimethylsilyluridine

Basic Information

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CAS Number

54925-71-2

Molecular Formula

C15H26N2O6Si

Molecular Weight

358.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

192-194 ºC (ethyl acetate hexane )

Density

1.25±0.1 g/cm3 (20 ºC 760 Torr),

SMILES

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OC[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C=C2)=O)=O)O1)O[Si](C)(C(C)(C)C)C)O

InChI

InChI=1S/C15H26N2O6Si/c1-15(2,3)24(4,5)23-12-11(20)9(8-18)22-13(12)17-7-6-10(19)16-14(17)21/h6-7,9,11-13,18,20H,8H2,1-5H3,(H,16,19,21)/t9-,11-,12-,13-/m1/s1

InChIKey

AYQZFVZTNUOLCQ-OJAKKHQRSA-N

LogP

0.1775999999999998

Topological Polar Surface Area

113.78000000000002 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

545

Synonyms & References

English

2'-TBDMS-RU
2'-O-(tert-butyldiMethylsilyl)uridine
1-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Uridine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]-
2'-o-tert-butyldimethylsilyluridine

MDL Number

MFCD28016405

FAQ

What is 2'-O-tert-Butyldimethylsilyluridine (CAS: 54925-71-2)?

2'-O-tert-Butyldimethylsilyluridine is a modified nucleoside commonly used in chemical synthesis and pharmaceutical research. It consists of a uracil base linked to a 2'-position ribose sugar, with a tert-butyldimethylsilyl group attached at the 2' position.

What are the main uses of 2'-O-tert-Butyldimethylsilyluridine (CAS: 54925-71-2)?

2'-O-tert-Butyldimethylsilyluridine is primarily used in the synthesis of nucleoside analogs for antiviral and anticancer drugs. It is also utilized in research to protect the ribose from hydrolysis, facilitating the study of nucleic acid chemistry and structure.

Is 2'-O-tert-Butyldimethylsilyluridine (CAS: 54925-71-2) safe?

2'-O-tert-Butyldimethylsilyluridine is generally safe when handled with appropriate protective measures. However, it should be used with caution, as it can cause skin irritation. Proper handling, including the use of gloves and goggles, is recommended.

How should 2'-O-tert-Butyldimethylsilyluridine (CAS: 54925-71-2) be stored?

2'-O-tert-Butyldimethylsilyluridine should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent degradation. Optimal storage conditions include a temperature between 10°C and 25°C and a relative humidity below 60%.