3-Nitro-4-pyridinol

Basic Information

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CAS Number

5435-54-1

Molecular Formula

C5H4N2O3

Molecular Weight

140.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

284°C

Boiling Point

480.8°C at 760 mmHg

Density

1.4480

Flash Point

244.6℃

SMILES

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C1=CNC=C(C1=O)[N+](=O)[O-]

InChI

InChI=1S/C5H4N2O3/c8-5-1-2-6-3-4(5)7(9)10/h1-3H,(H,6,8)

InChIKey

YUWOLBZMQDGRFV-UHFFFAOYSA-N

LogP

1.21860

Complexity

236

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Class IRRITANT-HARMFUL Class IRRITANT-HARMFUL

Synonyms & References

English

4-PYRIDINOL, 3-NITRO-
AKOS015891538
3-Nitropyridin-4(1H)-one
MFCD00051957
SCHEMBL220634
3-Nitro-4-pyridol
9G38RH5DF5
3-Nitro-4-hydroxypyridine
CS-W002397
PB12105
3-Nitro-4-pyridinol #
EU-0000171
NSC21465
J-515488
FT-0635705
AC-1398
BCP26473
4-Hydroxy-3-nitropyridine, 98%
AM20050837
FT-0616224
4-Hydroxy-3-nitropyridine
A3430
A7901
H1171
3-Nitro-pyridin-4-ol
DTXSID10935319
5435-54-1
15590-90-6
MFCD00128874
BCP22821
NS00124146

MDL Number

MFCD00128874

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Nitro-4-pyridinol (CAS: 5435-54-1)?

3-Nitro-4-pyridinol is a crystalline compound with a molecular weight of 165.11 g/mol. It has a solubility of 1.15 g/100 mL in water and is soluble in ethanol and methanol. Chemically, it is relatively stable but can undergo nitro reduction under certain conditions. Its properties include a melting point of 152-155°C and a boiling point of 250-255°C. It is a potent electrophile in organic synthesis.

How is 3-Nitro-4-pyridinol (CAS: 5435-54-1) typically synthesized?

3-Nitro-4-pyridinol is usually synthesized by the nitration of 4-pyridol or 3-pyridol. The nitration reaction involves treating the pyridol with concentrated nitric acid in the presence of a catalyst like sulfuric acid. The yield is typically around 70-80%, and the reaction is carried out under controlled temperature conditions to ensure high purity and selectivity.

What industries use 3-Nitro-4-pyridinol (CAS: 5435-54-1)?

3-Nitro-4-pyridinol is primarily used in the pharmaceutical industry as a precursor for the synthesis of various pyridine derivatives with potential medicinal applications. It is also used in the chemical industry for the production of dyes, pigments, and other organic compounds. Additionally, it finds applications in the development of sensors and as a reagent in organic synthesis.

What precautions should be taken when handling 3-Nitro-4-pyridinol (CAS: 5435-54-1)?

When handling 3-Nitro-4-pyridinol, it is crucial to use personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from heat and ignition sources. In case of spillage, the area should be ventilated, and a spill kit should be used to contain the spill. Emergency showers and eyewash stations should be readily accessible. Always refer to the Safety Data Sheet (SDS) for detailed safety information.