3-Nitro-4-pyridinol(CAS: 5435-54-1)

3-Nitro-4-pyridinol is a crystalline compound with a molecular weight of 165.11 g/mol. It has a solubility of 1.15 g/100 mL in water and is soluble in ethanol and methanol. Chemically, it is relatively stable but can undergo nitro reduction under certain conditions. Its properties include a melting point of 152-155°C and a boiling point of 250-255°C. It is a potent electrophile in organic synthesis.

3-Nitro-4-pyridinol is usually synthesized by the nitration of 4-pyridol or 3-pyridol. The nitration reaction involves treating the pyridol with concentrated nitric acid in the presence of a catalyst like sulfuric acid. The yield is typically around 70-80%, and the reaction is carried out under controlled temperature conditions to ensure high purity and selectivity.

3-Nitro-4-pyridinol is primarily used in the pharmaceutical industry as a precursor for the synthesis of various pyridine derivatives with potential medicinal applications. It is also used in the chemical industry for the production of dyes, pigments, and other organic compounds. Additionally, it finds applications in the development of sensors and as a reagent in organic synthesis.

When handling 3-Nitro-4-pyridinol, it is crucial to use personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from heat and ignition sources. In case of spillage, the area should be ventilated, and a spill kit should be used to contain the spill. Emergency showers and eyewash stations should be readily accessible. Always refer to the Safety Data Sheet (SDS) for detailed safety information.