Albendazole EP Impurity B (Albendazole Sulfoxide, Ricobendazole) | CAS No. 54029-12-8

Q: What is Albendazole EP Impurity B (CAS: 54029-12-8)?

Albendazole EP Impurity B, also known as Albendazole Sulfoxide or Ricobendazole, is a chemical compound with the formula C13H15N3O2S. It is a sulfur-containing derivative of Albendazole, commonly used as an impurity in pharmaceutical production. This compound exhibits low solubility in water and is typically a solid at room temperature. Its structure resembles Albendazole but includes a sulfoxide functional group, making it relevant in drug development and quality control.

Q: What are the main uses of Albendazole EP Impurity B (CAS: 54029-12-8)?

Albendazole EP Impurity B is primarily used in pharmaceutical research to identify and quantify impurities during the synthesis of Albendazole, an antiparasitic medication. It may also serve as a reference standard for analytical testing. Additionally, it is studied in chemical research for understanding oxidation pathways in benzimidazole compounds. Its applications are limited to controlled industrial and research settings due to its role as a byproduct in drug manufacturing.

Q: Is Albendazole EP Impurity B (CAS: 54029-12-8) safe?

Albendazole EP Impurity B is considered less toxic than its parent compound, Albendazole, but safety precautions are still necessary. It should be handled with care, using gloves and ventilation to avoid skin or respiratory exposure. Limited data suggest it may pose risks if ingested or inhaled in large quantities. Always follow safety guidelines from regulatory bodies like the FDA and ensure proper disposal to minimize environmental impact.

Q: How should Albendazole EP Impurity B (CAS: 54029-12-8) be stored?

Albendazole EP Impurity B should be stored in a cool, dry place, away from light and moisture, in a sealed, airtight container. It is recommended to maintain storage temperatures between 2-8°C to preserve stability. Avoid exposure to strong oxidizing agents, and ensure it is kept in a well-ventilated area. Proper labeling and storage conditions are critical to prevent degradation and ensure safety during handling.

Albendazole EP Impurity B (Albendazole Sulfoxide, Ricobendazole)

Basic Information

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CAS Number

54029-12-8

Molecular Formula

C12H15N3O3S

Molecular Weight

281.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

No data available

Melting Point

218-220 ºC

Boiling Point

No data available

Density

1.40

Flash Point

No data available

Solubility

Soluble in DMSO (11 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

SMILES

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CCCS(=O)C1=CC2=C(C=C1)N=C(N2)NC(=O)OC

InChI

InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

InChIKey

VXTGHWHFYNYFFV-UHFFFAOYSA-N

LogP

2.2588

Topological Polar Surface Area

84.07999999999998 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

353

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

Albendazole sulfoxide
Albendazole sulphoxide
AB01275491_02
Albendazolum oxidum
Albendazole-sulfoxide
Methyl 5-(propylsulfinyl)-2-benzimidazolecarbamate
Methyl (6-(propylsulfinyl)-1H-benzo[d]imidazol-2-yl)carbamate
methyl N-(6-propylsulfinyl-1H-benzimidazol-2-yl)carbamate
SCHEMBL321413
D81988
Methyl [5-(propane-1-sulfinyl)-1H-benzoimidazol-2-yl]-carbamate
Albendazolum oxidum [INN-Latin]
Albendazole S-oxide
N-(6-propylsulfinyl-1H-benzimidazol-2-yl)carbamic acid methyl ester
[5-(Propylsulfinyl)-1H-benzimidazol-2-yl]carbamic acid, methyl ester
(+/-)-albendazole sulfoxide
Oxido de albendazol
J39B52TV34
UNII-J39B52TV34
methyl [5-(propylsulfinyl)-1H-benzimidazol-2-yl]carbamate
s1836
Rycoben
Methyl (5-propylsulfoxy)2-benzimidazolecarbamate
Albendazole Oxide (Ricobendazole)
Carbamic acid, [5-(propylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester
RS-8852
SW219539-1
AKOS015961126
Methoxy-N-[5-(propylsulfinyl)benzimidazol-2-yl]carboxamide
Albendazole sulfoxide, VETRANAL(TM), analytical standard
methyl 5-(propylsulfinyl)-1H-benzo[d]imidazol-2-ylcarbamate

MDL Number

MFCD00797922

FAQ

What is Albendazole EP Impurity B (CAS: 54029-12-8)?

Albendazole EP Impurity B, also known as Albendazole Sulfoxide or Ricobendazole, is a chemical compound with the formula C13H15N3O2S. It is a sulfur-containing derivative of Albendazole, commonly used as an impurity in pharmaceutical production. This compound exhibits low solubility in water and is typically a solid at room temperature. Its structure resembles Albendazole but includes a sulfoxide functional group, making it relevant in drug development and quality control.

What are the main uses of Albendazole EP Impurity B (CAS: 54029-12-8)?

Albendazole EP Impurity B is primarily used in pharmaceutical research to identify and quantify impurities during the synthesis of Albendazole, an antiparasitic medication. It may also serve as a reference standard for analytical testing. Additionally, it is studied in chemical research for understanding oxidation pathways in benzimidazole compounds. Its applications are limited to controlled industrial and research settings due to its role as a byproduct in drug manufacturing.

Is Albendazole EP Impurity B (CAS: 54029-12-8) safe?

Albendazole EP Impurity B is considered less toxic than its parent compound, Albendazole, but safety precautions are still necessary. It should be handled with care, using gloves and ventilation to avoid skin or respiratory exposure. Limited data suggest it may pose risks if ingested or inhaled in large quantities. Always follow safety guidelines from regulatory bodies like the FDA and ensure proper disposal to minimize environmental impact.

How should Albendazole EP Impurity B (CAS: 54029-12-8) be stored?

Albendazole EP Impurity B should be stored in a cool, dry place, away from light and moisture, in a sealed, airtight container. It is recommended to maintain storage temperatures between 2-8°C to preserve stability. Avoid exposure to strong oxidizing agents, and ensure it is kept in a well-ventilated area. Proper labeling and storage conditions are critical to prevent degradation and ensure safety during handling.