4-(Benzyloxy)-2(1H)-pyridinone

Basic Information

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CAS Number

53937-02-3

Molecular Formula

C12H11NO2

Molecular Weight

201.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

201-203 °C

Boiling Point

464.3℃ at 760mmHg

Density

1.2±0.1 g/cm3

Flash Point

234.6±28.7 °C

Refractive Index

1.603

Vapor Pressure

0.0±1.1 mmHg at 25°C

SMILES

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C1=CC=C(C=C1)COC2=CC(=O)NC=C2

InChI

InChI=1S/C12H11NO2/c14-12-8-11(6-7-13-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,13,14)

InChIKey

DOVNUEPFPBWTSV-UHFFFAOYSA-N

LogP

1.9539

Topological Polar Surface Area

42.09 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

288

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4-benzyloxypyridin-2(1H)-one
AC-8943
4-(benzyl-oxy)pyridin-2(1H)-one
CHEMBL1475400
AKOS005254278
2(1H)-Pyridinone, 4-(phenylmethoxy)-
4-phenylmethoxy-1H-pyridin-2-one
4-benzyloxy-2(1H)pyridone
4-Benzyloxypyridin-2-one
4-Benzyloxy-2-(1H)-pyridone
4-BENZYLOXY-2-HYDROXYPYRIDINE
4-benzyloxy-pyridin-2-ol
4-benzyloxy-2-pyridone
4-(Benzyloxy)pyridin-2(1H)-one
4-benzyloxy-2(1H)-pyridinone
cid_3607724
4-Benzyloxy-2(1H)-pyridone
MLS001360006
DOVNUEPFPBWTSV-UHFFFAOYSA-N
A7835
SMR001224327
DTXSID30394121
4-benzyloxy-1H-pyridone
FS-2674
SR-03000003167
4-benzyloxy-pyridin-2(1H)-one
4-Benzyloxy-1H-pyridin-2-one
4-(Benzyloxy)pyridin-2-ol
SR-01000856298-2
53937-02-3
BDBM66219

MDL Number

MFCD04039771

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-(Benzyloxy)-2(1H)-pyridinone (CAS: 53937-02-3)?

4-(Benzyloxy)-2(1H)-pyridinone is a crystalline compound with a molecular weight of approximately 250.26 g/mol. It is poorly soluble in water but soluble in organic solvents such as methanol and ethanol. The compound is relatively stable and exhibits limited reactivity under normal conditions, making it suitable for various synthetic applications. It forms white to off-white crystals and is typically stored at room temperature away from direct sunlight.

How is 4-(Benzyloxy)-2(1H)-pyridinone (CAS: 53937-02-3) typically synthesized?

4-(Benzyloxy)-2(1H)-pyridinone is commonly synthesized through the condensation of benzylamine and 2-hydroxypyridine. The reaction proceeds efficiently with a yield of about 80%. The process typically involves heating the mixture under reflux conditions in the presence of an appropriate catalyst. Commonly used catalysts include phosphorus oxychloride or chlorotriethylsilane. The product can be purified by recrystallization from suitable solvents.

What industries use 4-(Benzyloxy)-2(1H)-pyridinone (CAS: 53937-02-3)?

4-(Benzyloxy)-2(1H)-pyridinone is primarily used in pharmaceuticals, where it serves as a precursor for the synthesis of various pyridone derivatives. It also finds applications in the production of polymers and sensors due to its unique chemical properties. Additionally, it is utilized in the semiconductor industry for specific applications requiring its physical and chemical characteristics.

What precautions should be taken when handling 4-(Benzyloxy)-2(1H)-pyridinone (CAS: 53937-02-3)?

When handling 4-(Benzyloxy)-2(1H)-pyridinone, it is crucial to wear protective equipment such as gloves, goggles, and a lab coat to prevent skin contact and inhalation. This compound should be used in a well-ventilated area or under a fume hood. In case of a spill, it is recommended to use appropriate absorbents and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.