4-(Benzyloxy)-2(1H)-pyridinone(CAS: 53937-02-3)

4-(Benzyloxy)-2(1H)-pyridinone is a crystalline compound with a molecular weight of approximately 250.26 g/mol. It is poorly soluble in water but soluble in organic solvents such as methanol and ethanol. The compound is relatively stable and exhibits limited reactivity under normal conditions, making it suitable for various synthetic applications. It forms white to off-white crystals and is typically stored at room temperature away from direct sunlight.

4-(Benzyloxy)-2(1H)-pyridinone is commonly synthesized through the condensation of benzylamine and 2-hydroxypyridine. The reaction proceeds efficiently with a yield of about 80%. The process typically involves heating the mixture under reflux conditions in the presence of an appropriate catalyst. Commonly used catalysts include phosphorus oxychloride or chlorotriethylsilane. The product can be purified by recrystallization from suitable solvents.

4-(Benzyloxy)-2(1H)-pyridinone is primarily used in pharmaceuticals, where it serves as a precursor for the synthesis of various pyridone derivatives. It also finds applications in the production of polymers and sensors due to its unique chemical properties. Additionally, it is utilized in the semiconductor industry for specific applications requiring its physical and chemical characteristics.

When handling 4-(Benzyloxy)-2(1H)-pyridinone, it is crucial to wear protective equipment such as gloves, goggles, and a lab coat to prevent skin contact and inhalation. This compound should be used in a well-ventilated area or under a fume hood. In case of a spill, it is recommended to use appropriate absorbents and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.