2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride

Basic Information

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CAS Number

52997-74-7

Molecular Formula

C9H11ClF3N

Molecular Weight

225.64 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

SMILES

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C1=CC(=CC=C1CCN)C(F)(F)F.Cl

InChI

InChI=1S/C9H10F3N.ClH/c10-9(11,12)8-3-1-7(2-4-8)5-6-13;/h1-4H,5-6,13H2;1H

InChIKey

MAPCNSROFGNSAV-UHFFFAOYSA-N

LogP

2.628400000000001

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

147

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

2-(4-(Trifluoromethyl)phenyl)ethanamine hydrochloride
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE HYDROCHLORIDE
2-(4-Trifluoromethyl-phenyl)-ethylamine, HCl
2-[4-(TRIFLUOROMETHYL)PHENYL]ETHANAMINE HYDROCHLORIDE
SB37525
DTXSID80610040
AKOS017343989
2-[4-(trifluoromethyl)phenyl]ethanamine;hydrochloride
FS-4416
Z235319541
2-(4-(trifluoromethyl)phenyl)ethanamine hydrochloride
2-(4-trifluoromethyl-phenyl)-ethylamine, AldrichCPR
2-(4-trifluoromethyl-phenyl)-ethylaminehydrochloride
2-(4-trifluoromethylphenyl)ethyl amine hcl
2-(4-(trifluoromethyl)phenyl)-ethylamine hydrochloride
2-[4-(trifluoromethyl)phenyl]ethanamine hydrochloride;2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE HCL
2-[4-(trifluoromethyl)phenyl]ethan-1-amine hydrochloride
2-[4-(Trifluoromethyl)phenyl]ethan-1-amine--hydrogen chloride (1/1)
F2147-0682
2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride
EN300-07637
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE HCL
SCHEMBL4369846
MAPCNSROFGNSAV-UHFFFAOYSA-N
2-(4-trifluoromethylphenyl)ethylamine hydrochloride
2-[4-(trifluoromethyl)phenyl]ethanamine hydrochloride
A829340
MFCD08436160
52997-74-7

MDL Number

MFCD08436160

Customs Code

2921499090

FAQ

What are the physical and chemical properties of 2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride (CAS: 52997-74-7)?

2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride is a white crystalline solid. Its molecular weight is approximately 265.67 g/mol. It has a high solubility in water (12.5 g/100 mL at 20°C) and is poorly soluble in organic solvents. The compound is mildly basic and can react with strong acids to form its hydrochloride salt. Its physical properties include a melting point of 170-172°C and a boiling point of 295°C (lit.).

How is 2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride (CAS: 52997-74-7) typically synthesized?

2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride is typically synthesized through a multistep process involving the protection of an amine function, subsequent introduction of a trifluoromethyl group, and finally the formation of the hydrochloride salt. The synthesis often involves reagents such as trifluoromethyl Grignard reagents and mild aqueous acid treatment. The process yields a product with high purity and selectivity.

What industries use 2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride (CAS: 52997-74-7)?

2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride is used in various industries, particularly in pharmaceuticals and fine chemicals. It serves as a precursor in the synthesis of medicinal compounds and is also utilized in the development of sensors and semiconductors due to its specific chemical properties.

What precautions should be taken when handling 2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride (CAS: 52997-74-7)?

When handling 2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or under a fume hood to avoid inhalation or skin contact. In case of a spill, immediately clean it up using appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for disposal. Proper training in chemical handling and emergency response is essential.