2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride(CAS: 52997-74-7)

2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride is a white crystalline solid. Its molecular weight is approximately 265.67 g/mol. It has a high solubility in water (12.5 g/100 mL at 20°C) and is poorly soluble in organic solvents. The compound is mildly basic and can react with strong acids to form its hydrochloride salt. Its physical properties include a melting point of 170-172°C and a boiling point of 295°C (lit.).

2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride is typically synthesized through a multistep process involving the protection of an amine function, subsequent introduction of a trifluoromethyl group, and finally the formation of the hydrochloride salt. The synthesis often involves reagents such as trifluoromethyl Grignard reagents and mild aqueous acid treatment. The process yields a product with high purity and selectivity.

2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride is used in various industries, particularly in pharmaceuticals and fine chemicals. It serves as a precursor in the synthesis of medicinal compounds and is also utilized in the development of sensors and semiconductors due to its specific chemical properties.

When handling 2-(4-Trifluoromethyl-phenyl)-ethylamine hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or under a fume hood to avoid inhalation or skin contact. In case of a spill, immediately clean it up using appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for disposal. Proper training in chemical handling and emergency response is essential.