Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (1:1) | CAS No. 50-13-5
Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (1:1)
Basic Information
CAS Number
50-13-5
Molecular Formula
C15H22ClNO2
Molecular Weight
283.8 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
186-189°
Boiling Point
282°C (rough estimate)
Flash Point
11 °C
Refractive Index
1.5200 (estimate)
Safety Information
View Safety InformationHazard Class
Class 6.1(b)
Class 6.1(b)
Toxicity
LD50 orally in rats: 170 mg/kg (Barlow, Lewis)
Synonyms & References
English
- PETHIDINE HYDROCHLORIDE (EP IMPURITY)
- Dolantin hydrochloride
- PETHIDINE HYDROCHLORIDE [EP MONOGRAPH]
- Pethidine chloride
- NSC 400479
- Dolopethin
- Pethidine Hydrochloride (Meperidine Hydrochloride)
- Petisel
- Isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride
- Meperidine hydrochloride (USP)
- 50-13-5 (HCl)
- Cluyer
- Pethidine hydrochloride
- Spasmedal
- MEPERIDINE HYDROCHLORIDE [USP MONOGRAPH]
- D01383
- Isonipecaine hydrochloride
- Dolantol
- Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate monohydrochloride
- Meperidine hydrochloride (USAN:USP)
- Sauteralgyl
- MEPERIDINE HYDROCHLORIDE [VANDF]
- Ethyl-1-methyl-4-phenylisonipecotate hydrochloride
- MEPERIDINE HYDROCHLORIDE [USAN]
- NSC400479
- Dolargan
- Dolosal
- ethyl 1-methyl-4-phenylpiperidine-4-carboxylate;hydrochloride
- 1-Methyl-4-phenylisonipecotic acid ethyl ester hydrochloride
- CHEMBL1701
- Synelaudine
FAQ
What are the physical and chemical properties of Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (CAS: 50-13-5)?
Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride is a white crystalline solid with a molecular weight of approximately 316.36 g/mol. It has a pKa of about 4.5 and is soluble in water and organic solvents like ethanol and methanol. This compound is reactive and susceptible to hydrolysis under acidic or basic conditions.
How is Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (CAS: 50-13-5) typically synthesized?
Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride is synthesized by reacting 1-methyl-4-phenyl-4-piperidinecarboxylic acid with ethyl chloroformate in the presence of a base such as triethylamine. The reaction is typically carried out at room temperature, and the product is isolated by recrystallization from a suitable solvent.
What industries use Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (CAS: 50-13-5)?
Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride finds applications in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the polymer industry for modifying properties of polymers and in the sensor industry for developing chemical sensors due to its reactivity and specific functional groups.
What precautions should be taken when handling Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (CAS: 50-13-5)?
When handling Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride, it is essential to wear proper personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight. Use a fume hood during handling to minimize exposure to vapors. In case of a spill, immediately clean it up and refer to the Safety Data Sheet (SDS) for specific spill cleanup procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
You might also like
Compound Q&A
What is 6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one (CAS: 21889-89-4)?
6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one is a cyclic ketone with a molecular for...
21889-89-46-Methyl-7-oxabicycl...
Compound Q&A
What is 4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid (CAS: 906353-00-2)?
4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid is a chemical compound with the CAS nu...
906353-00-24-[(6-Methyl-2-pyraz...
Compound Q&A
What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?
2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8) is a colorless to slightly yel...
49745-42-82-(2-Pyridinyl)-1,3-...
Compound Q&A
What is 2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile (CAS: 24783-42-4)?
2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile is an organic compound with the CA...
24783-42-42-(6-Chloro-2-pyridi...
Compound Q&A
What is 2-Oxopropanamide (CAS: 631-66-3)?
2-Oxopropanamide, also known as 2-aminoacrylic acid, is a chemical compound with...
631-66-32-Oxopropanamide
Compound Q&A
What is 2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CAS: 1289040-88-5)?
2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CA...
1289040-88-52-Methyl-2-propanyl ...
Compound Q&A
What is NAMPT inhibitor-linker 1 (CAS: 2241019-57-6)?
NAMPT inhibitor-linker 1 (CAS: 2241019-57-6) is a chemical compound designed as ...
2241019-57-6NAMPT inhibitor-link...
Compound Q&A
What is (2-(2,2,2-Trifluoroacetyl)pyridin-4-yl)boronic acid (CAS: 1310404-58-0)?
It is a chemical compound with the structure (2-(2,2,2-Trifluoroacetyl)pyridin-4...
1310404-58-0(2-(2,2,2-Trifluoroa...
Compound Q&A
What is 1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS: 794568-90-4)?
1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,...
794568-90-41-(2-Chlorophenyl)-6...
Compound Q&A
What is Vinyl(chloromethyl)dimethoxysilane (CAS: 1314981-48-0)?
Vinyl(chloromethyl)dimethoxysilane is an organosilicon compound with the molecul...
1314981-48-0Vinyl(chloromethyl)d...
