Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (1:1)(CAS: 50-13-5)

Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride is a white crystalline solid with a molecular weight of approximately 316.36 g/mol. It has a pKa of about 4.5 and is soluble in water and organic solvents like ethanol and methanol. This compound is reactive and susceptible to hydrolysis under acidic or basic conditions.

Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride is synthesized by reacting 1-methyl-4-phenyl-4-piperidinecarboxylic acid with ethyl chloroformate in the presence of a base such as triethylamine. The reaction is typically carried out at room temperature, and the product is isolated by recrystallization from a suitable solvent.

Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride finds applications in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the polymer industry for modifying properties of polymers and in the sensor industry for developing chemical sensors due to its reactivity and specific functional groups.

When handling Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride, it is essential to wear proper personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight. Use a fume hood during handling to minimize exposure to vapors. In case of a spill, immediately clean it up and refer to the Safety Data Sheet (SDS) for specific spill cleanup procedures.