Compound Q&A

How is Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (CAS: 50-13-5) typically synthesized?

Answer

Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (1:1)
Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride is synthesized by reacting 1-methyl-4-phenyl-4-piperidinecarboxylic acid with ethyl chloroformate in the presence of a base such as triethylamine. The reaction is typically carried out at room temperature, and the product is isolated by recrystallization from a suitable solvent.

About

CAS No 50-13-5
English Name Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (1:1)
Molecular Formula C15H22ClNO2
Molecular Weight 283.8 g/mol
SMILES CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2.Cl
InChIKey WCNLCIJMFAJCPX-UHFFFAOYSA-N
Last Updated: 2026-04-01 14:15

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