4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide

Basic Information

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CAS Number

49701-24-8

Molecular Formula

C9H14N2O4S

Molecular Weight

246.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

223ºC min.

Boiling Point

444.1 °C at 760 mmHg

Density

1.294

Flash Point

222.4 °C

Refractive Index

1.545

SMILES

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CNS(=O)(=O)C1=C(C=C(C(=C1)OC)N)OC

InChI

InChI=1S/C9H14N2O4S/c1-11-16(12,13)9-5-7(14-2)6(10)4-8(9)15-3/h4-5,11H,10H2,1-3H3

InChIKey

CISVVDNATRQDNU-UHFFFAOYSA-N

LogP

0.19409999999999955

Topological Polar Surface Area

90.65 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

314

Synonyms & References

English

NS00006391
SCHEMBL4610100
DTXSID2068507
A827810
GMB7RWW37D
2,5-DIMETHOXY-4-METHYLAMINOSULFONYLANILINE
N-Methyl-4-amino-2,5-dimethoxybenzenesulfonamide
EINECS 256-435-3
EC 256-435-3
D87750
AKOS015898693
4-amino-2,5-dimethoxy-N-methyl-benzenesulfonamide
W-106013
Benzenesulfonamide, 4-amino-2,5-dimethoxy-N-methyl-
FT-0617451
AC-1424
49701-24-8
4-amino-2,5-dimethoxy-N-methylbenzene-1-sulfonamide
4-amino-2,5-dimethoxy-N-methylbenzenesulfonamide
4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide
4-Amino-2,5-dimethoxybenzenesulfon-N-methylamide
4-AMINO-2,5-DIMETHOXY-N-METHYL-BENZENESULFONAMID
4-Amino-2,5-dimethoxy-N-methylbenzenesulphonamide
2,5-Dimethoxy-4-methylaminosulfonylaniline

MDL Number

MFCD02684421

Customs Code

2935009090

FAQ

What are the physical and chemical properties of 4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8)?

4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8) is a white or off-white crystalline solid with a molecular weight of approximately 317.38 g/mol. It is slightly soluble in water but more soluble in organic solvents like methanol and ethanol. The compound is known for its stability and moderate reactivity, particularly in nucleophilic substitution reactions. It has a low melting point of around 130°C and is relatively non-toxic but requires proper handling due to its potential to cause skin and eye irritation.

How is 4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8) typically synthesized?

4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8) is typically synthesized by the reaction of 2,5-dimethoxy-N-methylbenzenesulfonyl chloride with ammonia in the presence of a base such as sodium hydroxide. The reaction is carried out under mild conditions, and the product is isolated by filtration and recrystallization. The yield is usually around 85%, and the reaction is highly selective, making it a reliable method for its preparation.

What industries use 4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8)?

4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug compounds. It also finds applications in the polymer industry for modifying polymer properties and in the sensor industry due to its ability to act as a sensing element. Additionally, it is used in semiconductor manufacturing for its reactivity and stability.

What precautions should be taken when handling 4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8)?

When handling 4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8), it is important to use personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation. Spills should be cleaned up immediately with appropriate absorbent materials and disposed of in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and storage.