4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide(CAS: 49701-24-8)

4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8) is a white or off-white crystalline solid with a molecular weight of approximately 317.38 g/mol. It is slightly soluble in water but more soluble in organic solvents like methanol and ethanol. The compound is known for its stability and moderate reactivity, particularly in nucleophilic substitution reactions. It has a low melting point of around 130°C and is relatively non-toxic but requires proper handling due to its potential to cause skin and eye irritation.

4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8) is typically synthesized by the reaction of 2,5-dimethoxy-N-methylbenzenesulfonyl chloride with ammonia in the presence of a base such as sodium hydroxide. The reaction is carried out under mild conditions, and the product is isolated by filtration and recrystallization. The yield is usually around 85%, and the reaction is highly selective, making it a reliable method for its preparation.

4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug compounds. It also finds applications in the polymer industry for modifying polymer properties and in the sensor industry due to its ability to act as a sensing element. Additionally, it is used in semiconductor manufacturing for its reactivity and stability.

When handling 4-Amino-2,5-dimethoxy-N-methylbenzenesulfonamide (CAS: 49701-24-8), it is important to use personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation. Spills should be cleaned up immediately with appropriate absorbent materials and disposed of in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and storage.