(4-Chlorophenyl)(hydroxy)acetic acid

Basic Information

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CAS Number

492-86-4

Molecular Formula

C8H7ClO3

Molecular Weight

186.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

118.0 to 122.0 deg-C

Boiling Point

361.4℃ at 760 mmHg

Flash Point

172.4℃

Refractive Index

1.5250 (estimate)

SMILES

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C1=CC(=CC=C1C(C(=O)O)O)Cl

InChI

InChI=1S/C8H7ClO3/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7,10H,(H,11,12)

InChIKey

BWSFWXSSALIZAU-UHFFFAOYSA-N

LogP

1.4580000000000002

Topological Polar Surface Area

57.53 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

164

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

P-chloro mandelic acid
AKOS016046696
FT-0618219
2-(4-chlorophenyl)-2-hydroxyacetic acid
Para-chloromandelic acid
SY033507
NS00042504
7138-34-3
MFCD00042724
DTXSID30883404
p-Chloromandelic acid
FT-0695218
NOA 459119
Oprea1_557431
FT-0693821
2-(4-chlorophenyl)-2-hydroxy-acetic acid
p-chlorophenyl-alpha-hydroxyacetic acid
SB44316
A827692
Mandelic acid, p-chloro-
F8882-4321
Benzeneacetic acid, 4-chloro-alpha-hydroxy-
AI3-16648
SCHEMBL6366
4-Chloro-alpha-hydroxyphenylacetic acid
NSC-31400
EINECS 207-764-6
4-Chloro-.alpha.-hydroxybenzeneethanoic acid
4-Chloromandelic acid, AldrichCPR
Benzeneacetic acid, 4-chloro-.alpha.-hydroxy-
EN300-116835

MDL Number

MFCD00042724

Customs Code

2918199090

FAQ

What are the physical and chemical properties of (4-Chlorophenyl)(hydroxy)acetic acid (CAS: 492-86-4)?

(4-Chlorophenyl)(hydroxy)acetic acid is a white crystalline solid with a molecular weight of approximately 192.58 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive towards bases and can undergo esterification and amide formation. This compound is stable under normal conditions but should be stored in a dry place away from strong acids and bases.

How is (4-Chlorophenyl)(hydroxy)acetic acid (CAS: 492-86-4) typically synthesized?

(4-Chlorophenyl)(hydroxy)acetic acid is typically synthesized through the reaction of 4-chlorophenol with acetic anhydride in the presence of a catalyst such as pyridine. The reaction involves acetylation of the phenolic hydroxyl group, followed by deprotonation and re-protonation to form the desired compound. The yield is generally around 80-85%, and the method is scalable for industrial production.

What industries use (4-Chlorophenyl)(hydroxy)acetic acid (CAS: 492-86-4)?

(4-Chlorophenyl)(hydroxy)acetic acid is used in various industries. It is a key intermediate in the pharmaceutical industry for the synthesis of certain drugs. In the polymer industry, it can be used to modify polymers to improve their properties. Additionally, it has applications in the production of sensors and as a component in some formulations for semiconductor processing.

What precautions should be taken when handling (4-Chlorophenyl)(hydroxy)acetic acid (CAS: 492-86-4)?

When handling (4-Chlorophenyl)(hydroxy)acetic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work in a well-ventilated area or fume hood to avoid inhalation of the compound. Spills should be contained and cleaned up using absorbent materials. This substance should be stored in a cool, dry place away from heat sources and strong acids. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.