(4-Chlorophenyl)(hydroxy)acetic acid(CAS: 492-86-4)

(4-Chlorophenyl)(hydroxy)acetic acid is a white crystalline solid with a molecular weight of approximately 192.58 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive towards bases and can undergo esterification and amide formation. This compound is stable under normal conditions but should be stored in a dry place away from strong acids and bases.

(4-Chlorophenyl)(hydroxy)acetic acid is typically synthesized through the reaction of 4-chlorophenol with acetic anhydride in the presence of a catalyst such as pyridine. The reaction involves acetylation of the phenolic hydroxyl group, followed by deprotonation and re-protonation to form the desired compound. The yield is generally around 80-85%, and the method is scalable for industrial production.

(4-Chlorophenyl)(hydroxy)acetic acid is used in various industries. It is a key intermediate in the pharmaceutical industry for the synthesis of certain drugs. In the polymer industry, it can be used to modify polymers to improve their properties. Additionally, it has applications in the production of sensors and as a component in some formulations for semiconductor processing.

When handling (4-Chlorophenyl)(hydroxy)acetic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work in a well-ventilated area or fume hood to avoid inhalation of the compound. Spills should be contained and cleaned up using absorbent materials. This substance should be stored in a cool, dry place away from heat sources and strong acids. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.