2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine

Basic Information

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CAS Number

448964-37-2

Molecular Formula

C13H17NO

Molecular Weight

203.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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C1CC2=C(C1CCN)C3=C(C=C2)OCC3

InChI

InChI=1S/C13H17NO/c14-7-5-10-2-1-9-3-4-12-11(13(9)10)6-8-15-12/h3-4,10H,1-2,5-8,14H2

InChIKey

BFNUHWYOQCGTCA-UHFFFAOYSA-N

LogP

2.0000999999999998

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

231

Synonyms & References

English

448964-37-2
2-(1,6,7,8-tetrahydro-2H-indeno [5,4-b] furan-8-yl)ethylamine
2-(2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethanamine
AKOS016005423
Discontinued see: D297275''
2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethan-1-amine
SCHEMBL11917773
FT-0774273
BFNUHWYOQCGTCA-UHFFFAOYSA-N
2-{1H,2H,6H,7H,8H-INDENO[5,4-B]FURAN-8-YL}ETHANAMINE
2-(2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethanamine
FT-0666269
SB67398
CS-M1901
SCHEMBL340076
BCP12291
Discontinued see: D297275
DTXSID00433394
2-(1,6,7,8,-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine
2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine
CS-14199
rac Despropionyl Ramelteon
rac Despropionyl Ramelteon Discontinued see: D297275
1,6,7,8-tetrahydro-2H-Indeno[5,4-b]furan-8-ethanamine
rac Despropionyl Ramelteon Discontinued see: D297275
2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine
2,4-DITRIFLUOROMETHYL-6-METHOXY-BENZOIC ACID
N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]amine
rac Despropionyl Ramelteon Discontinued see: D297275
AX8236576
ST24039121

MDL Number

MFCD11865054

Customs Code

2932999099

FAQ

What are the physical and chemical properties of 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine (CAS: 448964-37-2)?

2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine is a crystalline solid with a molecular weight of approximately 243.31 g/mol. It has a moderate solubility in organic solvents like ethanol and acetone but is poorly soluble in water. Chemically, it exhibits basic properties due to the amine group and is generally stable under normal conditions but reactive towards strong acids and bases. It has a melting point of around 100-102°C and a boiling point of about 255-257°C.

How is 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine (CAS: 448964-37-2) typically synthesized?

2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine can be synthesized via a multistep process involving the Wittig reaction followed by amine coupling. The key steps include the preparation of the indeno-furan derivative, followed by treatment with an appropriate alkyl halide in the presence of a base to form the ethyl amine derivative. The overall reaction is typically carried out under mild conditions, with yields ranging from 70-85%.

What industries use 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine (CAS: 448964-37-2)?

2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine finds applications in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of certain drugs. It is also utilized in the production of polymers, sensors, and semiconductors, where its functional groups make it useful for modifying the properties of materials.

What precautions should be taken when handling 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine (CAS: 448964-37-2)?

When handling 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.