2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine(CAS: 448964-37-2)

2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine is a crystalline solid with a molecular weight of approximately 243.31 g/mol. It has a moderate solubility in organic solvents like ethanol and acetone but is poorly soluble in water. Chemically, it exhibits basic properties due to the amine group and is generally stable under normal conditions but reactive towards strong acids and bases. It has a melting point of around 100-102°C and a boiling point of about 255-257°C.

2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine can be synthesized via a multistep process involving the Wittig reaction followed by amine coupling. The key steps include the preparation of the indeno-furan derivative, followed by treatment with an appropriate alkyl halide in the presence of a base to form the ethyl amine derivative. The overall reaction is typically carried out under mild conditions, with yields ranging from 70-85%.

2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine finds applications in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of certain drugs. It is also utilized in the production of polymers, sensors, and semiconductors, where its functional groups make it useful for modifying the properties of materials.

When handling 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.